反应条件
1: NH3 / ethanol / 8 h / 180 °C
2: H2 / PtO2 / acetic acid / 3 h / 25 - 60 °C / 2327.2 Torr
3: 1.) dimethyl sulfate, 2.) K2CO3 / 1.) CHCl3, reflux, 5 h
4: 1.) LDA / 1.) THF, -78 to 0 deg C, 5 min, 2.) THF
5: 67 mg / NaIO4 / methanol; H2O / 2.5 h
6: toluene / 2.5 h / Heating
View Scheme
参考文献
Rasmusson, Gary H.; Reynolds, Glenn F.; Utne, Torleif; Jobson, Ronald B.; Primka, Raymond L.; et al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1690 - 1701
