3,5-二氟-2-甲氧基苯硼酸合成路线 (共 2 条)
反应条件
1: With n-butyllithium in tetrahydrofuran; diethyl ether T=-78°C; 0.0333333 h; 2: With tri-isopropoxy-borane in tetrahydrofuran; diethyl ether T=-78 - 20°C; 3: With hydrogenchloride in tetrahydrofuran; diethyl ether 0.5 h; Further stages.;
参考文献
Jones, Lyn H.; Randall, Amy; Barba, Oscar; Selby, Matthew D.
Organic and Biomolecular Chemistry, 2007 , vol. 5, # 21 p. 3431 - 3433
反应条件
1: With boron tribromide in dichloromethane T=0°C; 2 h; 2: With water in dichloromethane Cooling with ice;
参考文献
SMITHKLINE BEECHAM CORPORATION; BOUILLOT, Anne Marie Jeanne; DODIC, Nerina; GELLIBERT, Francoise Jeanne; MIRGUET, Olivier
Patent: WO2010/15652 A2, 2010 ;
Location in patent: Page/Page column 74 ;
WO 2010/015652 A2