3-[4-(二甲基氨基)苯基]丙酸合成路线 （共 8 条）
反应条件
ueber das Saeurechlorid und -azid;
参考文献
Ashley; Leeds
Journal of the Chemical Society, 1957 , p. 2706,2710
反应条件
1: With potassium carbonate; Pd-Tedicyp catalyst in N,N-dimethyl-formamide
T=110°C; Heck reaction; 20 h;
2: With sodium hydroxide; water in N,N-dimethyl-formamide
T=50 - 80°C;
参考文献
Lemhadri, Mhamed; Doucet, Henri; Santelli, Maurice
Tetrahedron, 2004 , vol. 60, # 50 p. 11533 - 11540
反应条件
formic acid; triethylamine in ethanol; water; ethyl acetate; acetone
参考文献
Biogal Gyogyszergrar
Patent: US5350872 A1, 1994 ;
参考文献
Terumo Kabushiki Kaisha
Patent: US6069149 A1, 2000 ;
反应条件
1: 71.3 percent / pyridine / 1 h / 0 - 2 °C
2: 93.7 percent / dimethylsulfoxide / 1) 93 deg C, 1.5h, 2) 100 deg C, 1h
3: 43.3 percent / conc. H2SO4, H2O / 0.5 h / Heating
View Scheme
参考文献
Byun, Young-Seok; Lightner, D. A.
Tetrahedron, 1991 , vol. 47, # 47 p. 9759 - 9772
反应条件
sodium amalgam; ethanol
参考文献
Weil
Monatshefte fuer Chemie, 1908 , vol. 29, p. 903
反应条件
1: sodium
2: alcohol; sodium amalgam
View Scheme
参考文献
Weil
Monatshefte fuer Chemie, 1908 , vol. 29, p. 903
参考文献
Shoppee
Journal of the Chemical Society, 1930 , p. 968,979
