3,3-二甲基-1-乙基-2-亚甲基吲哚啉合成路线 （共 5 条）
反应条件
in 1,4-dioxane T=95 - 100°C; 5.5 h;
参考文献
Shachkus, A. A.; Degutis, Yu. A.; Mikul'skis, P. P.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1989 , vol. 25, # 1 p. 47 - 50
Khimiya Geterotsiklicheskikh Soedinenii, 1989 , # 1 p. 57 - 59
反应条件
sodium hydroxide in water
T=20°C; 1 h;
参考文献
DALIAN CHROMAS BIOSCIENCE CO., LTD; DALIAN UNIVERSITY OF TECHNOLOGY
Patent: US2012/296098 A1, 2012 ;
Location in patent: Page/Page column 2-3 ;
反应条件
2: KOH-solution
View Scheme
参考文献
Plancher; Bettinelli
Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti, 1898 , vol. <5> 7 I, p. 372
Gazzetta Chimica Italiana, 1899 , vol. 29 I, p. 87
反应条件
1.1: 4 h / 70 - 80 °C
1.2: 4 h / 90 °C / oil bath
2.1: toluene / 7 h / Reflux; Inert atmosphere
3.1: sodium hydroxide / water / 1 h / 20 °C
View Scheme
参考文献
DALIAN CHROMAS BIOSCIENCE CO., LTD; DALIAN UNIVERSITY OF TECHNOLOGY
Patent: US2012/296098 A1, 2012 ;
反应条件
1.1: 4 h / 70 - 80 °C
1.2: 4 h / 90 °C / oil bath
2.1: toluene / 7 h / Reflux; Inert atmosphere
3.1: sodium hydroxide / water / 1 h / 20 °C
View Scheme
参考文献
DALIAN CHROMAS BIOSCIENCE CO., LTD; DALIAN UNIVERSITY OF TECHNOLOGY
Patent: US2012/296098 A1, 2012 ;
