4-(2-(4-((1-((4-氟苯基)甲基)-1H-苯并咪唑-2-基)氨基)-1-哌啶基)乙基)-苯酚合成路线 （共 15 条）
反应条件
hydrogen bromide 20 h; Heating;
参考文献
Janssens, Frans; Torremans, Joseph; Janssen, Marcel; Stokbroekx, Raymond A.; Luyckx, Marcel; Janssen, Paul A. J.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1934 - 1943
反应条件
hydrogen; palladium on activated charcoal in methanol
参考文献
Janssens, Frans; Torremans, Joseph; Janssen, Marcel; Stokbroekx, Raymond A.; Luyckx, Marcel; Janssen, Paul A. J.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1934 - 1943
反应条件
1: 40 percent / sodium carbonate, potassium iodide / dimethylformamide / 70 °C 2: 82 percent / 48 percent hydrobromic acid / 1 h / Heating 3: 46.7 percent / Na2CO3 / dimethylformamide / 20 h / 70 °C 4: 88.5 percent / H2 / 10 percent Pd/C / methanol View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 12 p. 1934 - 1943
反应条件
1: 82 percent / 48 percent hydrobromic acid / 1 h / Heating 2: 46.7 percent / Na2CO3 / dimethylformamide / 20 h / 70 °C 3: 88.5 percent / H2 / 10 percent Pd/C / methanol View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 12 p. 1934 - 1943
反应条件
1: 46.7 percent / Na2CO3 / dimethylformamide / 20 h / 70 °C 2: 88.5 percent / H2 / 10 percent Pd/C / methanol View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 12 p. 1934 - 1943
反应条件
1: 40 percent / sodium carbonate, potassium iodide / dimethylformamide / 70 °C 2: 82 percent / 48 percent hydrobromic acid / 1 h / Heating 3: 46.7 percent / Na2CO3 / dimethylformamide / 20 h / 70 °C 4: 88.5 percent / H2 / 10 percent Pd/C / methanol View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 12 p. 1934 - 1943
反应条件
1: 46.7 percent / Na2CO3 / dimethylformamide / 20 h / 70 °C 2: 88.5 percent / H2 / 10 percent Pd/C / methanol View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 12 p. 1934 - 1943
反应条件
1: 48 percent / Na2CO3 / dimethylformamide / 70 °C 2: 93 percent / 48 percent hydrobromic acid / 20 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 12 p. 1934 - 1943
反应条件
cytochrome P450 BM3 variant A78F T=37°C; 1 h; aq. phosphate bufferEnzymatic reaction;
参考文献
Chemistry - A European Journal, , vol. 15, # 43 p. 11723 - 11729
反应条件
cytochrome P450 BM3 chimera variant 21113312 T=37°C; 1 h; aq. phosphate bufferEnzymatic reaction;
参考文献
Chemistry - A European Journal, , vol. 15, # 43 p. 11723 - 11729
