4,5-二碘-2-甲基咪唑合成路线 （共 6 条）
反应条件
iodine; sodium carbonate in 1,4-dioxane; water T=20°C; 24 h;
参考文献
ACTELION PHARMACEUTICALS LTD
Patent: WO2008/78291 A1, 2008 ;
Location in patent: Page/Page column 62 ;
WO 2008/078291 A1
反应条件
iodine cloride; triethylamine in dichloromethane
反应条件
sodium nitrate; perchloric acid; triiodide monoanion; iodide in water T=30°C; 48 h; buffer and hydrogen ion dependence; KineticsMechanism;
参考文献
Journal of Organic Chemistry, , vol. 45, # 15 p. 3108 - 3111
反应条件
sodium sulfite in ethanol; water T=100°C; 24 h;
参考文献
Hendricks, Robert Than; Hermann, Johannes; Kondru, Rama; Lou, Yan; Lynch, Stephen M.; Owens, Timothy D.; Soth, Michael
Patent: US2011/230462 A1, 2011 ;
Location in patent: Page/Page column 109 ;
US 20110230462 A1
反应条件
in tetrahydrofuran; water
参考文献
Pfizer Inc.
Patent: US4740513 A1, 1988 ;
反应条件
sodium hydroxide in water T=40°C;
参考文献
Bahnous, Mebarek; Bouraiou, Abdelmalek; Chelghoum, Meryem; Bouacida, Sofiane; Roisnel, Thierry; Smati, Farida; Bentchouala, Chafia; Gros, Philippe C.; Belfaitah, Ali
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 5 p. 1274 - 1278
