(7-甲氧基-6-甲基-5,8-二氧代异喹啉-1-基)甲基(E)-2-甲基丁-2-烯酸酯合成路线 （共 36 条）
反应条件
salcomine; oxygen in N,N-dimethyl-formamide
T=20°C; 2 h;
参考文献
Kuwabara, Nagako; Hayashi, Hiroyuki; Hiramatsu, Noriko; Choshi, Tominari; Kumemura, Teppei; Nobuhiro, Junko; Hibino, Satoshi
Tetrahedron, 2004 , vol. 60, # 13 p. 2943 - 2952
反应条件
argentic oxide in 1,4-dioxane; nitric acid
参考文献
Danishefsky; Berman; Cvetovich; Minamikawa
Tetrahedron Letters, 1980 , vol. 21, # 50 p. 4819 - 4822
反应条件
selenium(IV) oxide; toluene-4-sulfonic acid in 1,4-dioxane
T=80°C; 14 h;
参考文献
Saito, Naoki; Tanaka, Chieko; Koizumi, Yu-Ichi; Suwanborirux, Khanit; Amnuoypol, Surattana; Pummangura, Sunibhond; Kubo, Akinori
Tetrahedron, 2004 , vol. 60, # 17 p. 3873 - 3881
反应条件
sodium hydroxide in methanol; dichloromethane; water
0.0166667 h; Ambient temperature;
参考文献
Frincke; Faulkner
Journal of the American Chemical Society, 1982 , vol. 104, # 1 p. 265 - 269
反应条件
in diethyl ether; dichloromethane
T=0°C; 0.5 h; Yield given;
参考文献
Frincke; Faulkner
Journal of the American Chemical Society, 1982 , vol. 104, # 1 p. 265 - 269
反应条件
1: K2CO3 / CHCl3
2: dichloroacetic acid
4: H2 / Pd/C / methanol
5: 65 percent / chloranil / xylene / 150 °C
6: 70 percent / di-isobutyl aluminiumhydride / tetrahydrofuran / 0 °C
7: 55 percent / DCC, dimethylaminopyridine / diethyl ether
8: 52 percent / AgO / dioxane; aq. HNO3
View Scheme
参考文献
Danishefsky; Berman; Cvetovich; Minamikawa
Tetrahedron Letters, 1980 , vol. 21, # 50 p. 4819 - 4822
反应条件
1: dimethylsulfoxide
2: borane-THF
3: K2CO3 / CHCl3
4: dichloroacetic acid
6: H2 / Pd/C / methanol
7: 65 percent / chloranil / xylene / 150 °C
8: 70 percent / di-isobutyl aluminiumhydride / tetrahydrofuran / 0 °C
9: 55 percent / DCC, dimethylaminopyridine / diethyl ether
10: 52 percent / AgO / dioxane; aq. HNO3
View Scheme
参考文献
Danishefsky; Berman; Cvetovich; Minamikawa
Tetrahedron Letters, 1980 , vol. 21, # 50 p. 4819 - 4822
反应条件
1: borane-THF
2: K2CO3 / CHCl3
3: dichloroacetic acid
5: H2 / Pd/C / methanol
6: 65 percent / chloranil / xylene / 150 °C
7: 70 percent / di-isobutyl aluminiumhydride / tetrahydrofuran / 0 °C
8: 55 percent / DCC, dimethylaminopyridine / diethyl ether
9: 52 percent / AgO / dioxane; aq. HNO3
View Scheme
参考文献
Danishefsky; Berman; Cvetovich; Minamikawa
Tetrahedron Letters, 1980 , vol. 21, # 50 p. 4819 - 4822
反应条件
1: dichloroacetic acid
3: H2 / Pd/C / methanol
4: 65 percent / chloranil / xylene / 150 °C
5: 70 percent / di-isobutyl aluminiumhydride / tetrahydrofuran / 0 °C
6: 55 percent / DCC, dimethylaminopyridine / diethyl ether
7: 52 percent / AgO / dioxane; aq. HNO3
View Scheme
参考文献
Danishefsky; Berman; Cvetovich; Minamikawa
Tetrahedron Letters, 1980 , vol. 21, # 50 p. 4819 - 4822
反应条件
1: H2 / Pd/C / methanol
2: 65 percent / chloranil / xylene / 150 °C
3: 70 percent / di-isobutyl aluminiumhydride / tetrahydrofuran / 0 °C
4: 55 percent / DCC, dimethylaminopyridine / diethyl ether
5: 52 percent / AgO / dioxane; aq. HNO3
View Scheme
参考文献
Danishefsky; Berman; Cvetovich; Minamikawa
Tetrahedron Letters, 1980 , vol. 21, # 50 p. 4819 - 4822
