6-氯烟酸甲酯合成路线

参考文献

Otrubova, Katerina; Cravatt, Benjamin F.; Boger, Dale L.
Journal of Medicinal Chemistry, 2014 , vol. 57, # 3 p. 1079 - 1089

73781-91-66-氯烟酸甲酯+

57260-71-61-Boc-哌嗪

201809-22-56-[4-(叔丁氧羰酰)哌嗪-1-YL]烟酸

参考文献

McGuinness, Brian F.; Carroll, Carolyn DiIanni; Zawacki, Lisa Guise; Dong, Guizhen; Yang, Cangming; Hobbs, Doug W.; Jacob-Samuel, Biji; Hall III, James W.; Jenh, Chung-Her; Kozlowski, Joseph A.; Anilkumar, Gopinadhan N.; Rosenblum, Stuart B.
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 17 p. 5205 - 5208

73781-91-66-氯烟酸甲酯

216955-75-86-(1H-咪唑-1-基)-3-吡啶羧酸

参考文献

ARGUSINA INC.; LIAO, Jiayu; HONG, Yufeng; WANG, Yong; VON GELDERN, Thomas W.; ZHANG, Kanyin E.
Patent: WO2011/94890 A1, 2011 ;
WO 2011/094890 A1

73781-91-66-氯烟酸甲酯+

75-89-82,2,2-三氟乙醇

287979-27-56-(2,2,2-三氟乙氧基)烟酸甲酯

参考文献

WO2010/146351 A1, ;

Page/Page column 57-58 ;
WO 2010/146351 A1

73781-91-66-氯烟酸甲酯+

6638-79-5二甲羟胺盐酸盐

149281-42-56-氯-n-甲氧基-n-甲基烟酰胺

参考文献

ELI LILLY AND COMPANY
Patent: WO2005/118542 A1, 2005 ;
Location in patent: Page/Page column 85-86 ;
WO 2005/118542 A1

73781-91-66-氯烟酸甲酯

21543-49-72-氯-5-羟甲基吡啶

参考文献

Lee, Chi-Lik Ken; Loh, Teck-Peng
Organic Letters, 2005 , vol. 7, # 14 p. 2965 - 2967

73781-91-66-氯烟酸甲酯

26218-78-06-溴烟酸甲酯

参考文献

ELI LILLY AND COMPANY
Patent: WO2004/94382 A1, 2004 ;
Location in patent: Page 17-18 ;
WO 2004/094382 A1

73781-91-66-氯烟酸甲酯+

5188-07-8甲硫醇钠

74470-40-96-(甲基硫代)烟酸甲酯

参考文献

KOWA COMPANY, LTD.
Patent: US2010/48610 A1, 2010 ;
Location in patent: Page/Page column 25 ;
US 20100048610 A1

73781-91-66-氯烟酸甲酯+

139301-27-24-三氟甲氧基苯硼酸

851266-73-46-(4-(三氟甲氧基)苯基)烟酸

参考文献

BAYER HEALTHCARE AG
Patent: WO2005/40100 A1, 2005 ;
Location in patent: Page/Page column 107-108 ;
WO 2005/040100 A1

73781-91-66-氯烟酸甲酯

87246-22-8

参考文献

Unangst, Paul C.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 495 - 499