1: 4-chloro pyridine hydrochloride With lithium diisopropyl amide in tetrahydrofuran 2: N,N-dimethyl-formamide in tetrahydrofuran T=20°C; Product distribution / selectivity;
参考文献
ACHAOGEN, INC.
Patent: WO2009/55696 A1, 2009 ;
Location in patent: Page/Page column 87-88 ;
1: 4-chloro pyridine hydrochloride With sodium carbonate in water 2: With n-butyllithium; N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=-78°C; 1 h; Inert atmosphere; 3: carbon dioxide in tetrahydrofuran T=20°C; 12 h; Inert atmosphere;
sodium t-butanolate; 2-dicyclohexylphosphino-1,1'-biphenyl; palladium diacetate in 1,4-dioxane T=100°C; Arylation; 22 h; Title compound not separated from byproducts.;
参考文献
Wolfe, John P.; Tomori, Hiroshi; Sadighi, Joseph P.; Yin, Jingjun; Buchwald, Stephen L.
Journal of Organic Chemistry, 2000 , vol. 65, # 4 p. 1158 - 1174
