5-溴-2,2-二甲基-1,3-苯并二噁茂合成路线 （共 10 条）
反应条件
1: 1-bromo-3,4-dimethoxy-benzene With boron tribromide in dichloromethane 18 h; Heating / reflux; 2: With sodium hydroxide in dichloromethane; water 3: 2,2-dimethoxy-propane With phosphorus pentoxide in dichloromethane; water T=90°C; 4 h;
参考文献
SMITHKLINE BEECHAM CORPORATION; CYTOKINETICS
Patent: WO2006/20358 A2, 2006 ;
Location in patent: Page/Page column 39-40 ;
反应条件
bromine in 1,4-dioxane
参考文献
Meltzer, Peter C.; McPhee, Mark; Madras, Bertha K.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 4133 - 4137
反应条件
P2O5; sodium chloride in acetone
反应条件
toluene-4-sulfonic acid in benzene 72 h; Heating;
参考文献
Ding, Y.-S.; Shiue, C.-Y.; Fowler, J. S.; Wolf, A. P.; Plenevaux, A.
Journal of Fluorine Chemistry, 1990 , vol. 48, # 2 p. 189 - 205
反应条件
1: 93 percent / p-TSA 2: 94 percent / Br2 / dioxane View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 22 p. 4133 - 4137
反应条件
1: 92 percent / BBr3 / CH2Cl2 / 20 h / Heating 2: 25 percent / p-toluenesulfonic acid / benzene / 72 h / Heating View Scheme
参考文献
Journal of Fluorine Chemistry, , vol. 48, # 2 p. 189 - 205
反应条件
bromine; acetic anhydride
参考文献
Recueil des Travaux Chimiques des Pays-Bas, , vol. 54, p. 995,999
参考文献
Slooff
Recueil des Travaux Chimiques des Pays-Bas, 1935 , vol. 54, p. 995,999
反应条件
1: 86 percent / butyl-lithium / hexane; tetrahydrofuran / -78 °C
2: 82 percent / lithium aluminium hydride / diethyl ether / 6 h
View Scheme
参考文献
Sargent, Melvyn V.; Wangchareontrakul, Sirichai
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1989 , p. 431 - 439
反应条件
1: aqueous H2SO4
View Scheme
参考文献
Slooff
Recueil des Travaux Chimiques des Pays-Bas, 1935 , vol. 54, p. 995,999
