1-甲氧基-4-苯基乙炔苯合成路线 （共 169 条）
参考文献
Hay; Allan S.; Paventi; Martino
Patent: US5233046 A1, 1993 ;
反应条件
diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide
T=80°C; Sonogashira coupling;
参考文献
Csekei, Marton; Novak, Zoltan; Kotschy, Andras
Tetrahedron, 2008 , vol. 64, # 6 p. 975 - 982
反应条件
oxygen; lithium chloride; manganese (II) chloride in tetrahydrofuran
T=0°C; 1 h; Inert atmosphere;
参考文献
Cahiez, Gerard; Duplais, Christophe; Buendia, Julien
Angewandte Chemie, International Edition, 2009 , vol. 48, # 36 p. 6731 - 6734
反应条件
potassium phosphate; copper(l) iodide; ethylene glycol in ethanol
T=100°C; Suzuki Coupling; 12 h; Schlenk techniqueInert atmosphere;
参考文献
Liu, Jidan; Dai, Fenglin; Yang, Zhiyong; Wang, Sizhuo; Xie, Kai; Wang, Anwei; Chen, Xiang; Tan, Ze
Tetrahedron Letters, 2012 , vol. 53, # 42 p. 5678 - 5683
反应条件
copper; zinc; bis(cyclopentadienyl)titanium dichloride; bis-triphenylphosphine-palladium(II) chloride in ethylene glycol dimethyl ether
T=60°C; 3 h;
参考文献
Tamaru, Yoshinao; Ochiai, Hirofumi; Yoshida, Zen-ichi
Tetrahedron Letters, 1984 , vol. 25, # 35 p. 3861 - 3864
反应条件
caesium carbonate; bis(dibenzylideneacetone)-palladium(0) in methanol
T=20°C; Suzuki-Miyaura cross-coupling reaction; 36 h; Under air;
参考文献
Tang, Jian-Sheng; Tian, Mi; Sheng, Wen-Bing; Guo, Can-Cheng
Synthesis, 2012 , vol. 44, # 4 p. 541 - 546
反应条件
palladium diacetate; dimethyl sulfoxide
T=20°C; Sonogashira Cross-Coupling; 0.166667 h;
参考文献
Barbero, Margherita; Cadamuro, Silvano; Dughera, Stefano
European Journal of Organic Chemistry, 2014 , vol. 2014, # 3 p. 598 - 605
反应条件
sec.-butyllithium in diethyl ether
adding of s-BuLi -110 deg C, then after 15 min adding of PhLi and 30 min at 0 deg C;
参考文献
Martin, Sophie; Sauvetre, Raymond; Normant, Jean-F.
Tetrahedron Letters, 1982 , vol. 23, # 42 p. 4329 - 4332
反应条件
1: n-BuLi, HMDS / tetrahydrofuran; hexane / 1.) -78 deg C, 10 min, 2.) -78 deg C to r.t., 30 min
2: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -60 - 0 °C
View Scheme
参考文献
Mouries, Virginie; Waschbuesch, Rachel; Carran, John; Savignac, Philippe
Synthesis, 1998 , # 3 p. 271 - 274
反应条件
tetrakis(triphenylphosphine) palladium(0); potassium acetate in butan-1-ol
T=80°C; 48 h;
参考文献
Catellani, Marta; Chiusoli, Gian Paolo; Mari, Aristodemo
Journal of Organometallic Chemistry, 1984 , vol. 275, # 1 p. 129 - 138
