1-甲氧基-4-苯基乙炔苯合成路线 （共 169 条）
反应条件
1: Pd(PPh3)4; Et3N / dimethylformamide / 6 h / 60 °C
2: 64 percent Chromat. / CuCl; Pd(PPh3)4 / dimethylformamide / 80 °C
View Scheme
参考文献
Nishihara, Yasushi; Ikegashira, Kazutaka; Hirabayashi, Kazunori; Ando, Jun-Ichi; Mori, Atsunori; Hiyama, Tamejiro
Journal of Organic Chemistry, 2000 , vol. 65, # 6 p. 1780 - 1787
反应条件
1: tetrahydrofuran / 14 h / 20 - 65 °C
2: 30 percent / tetrabutylammonium fluoride / (η3-C3H5PdCl)2 / tetrahydrofuran / 48 h / 60 °C
View Scheme
参考文献
Rossi, Renzo; Carpita, Adriano; Messeri, Tommaso
Gazzetta Chimica Italiana, 1992 , vol. 122, # 1 p. 65 - 72
反应条件
1: tetrahydrofuran / 2.5 h / Heating
2: tetrahydrofuran / 14 h / 20 - 65 °C
3: 30 percent / tetrabutylammonium fluoride / (η3-C3H5PdCl)2 / tetrahydrofuran / 48 h / 60 °C
View Scheme
参考文献
Rossi, Renzo; Carpita, Adriano; Messeri, Tommaso
Gazzetta Chimica Italiana, 1992 , vol. 122, # 1 p. 65 - 72
反应条件
sodium periodate in water; ethyl acetate
T=20°C; 0.95 h;
参考文献
Takale, Balaram S.; Telvekar, Vikas N.
Chemistry Letters, 2010 , vol. 39, # 12 p. 1279 - 1280
反应条件
copper(l) iodide; [PdCl2(2,2'-bipyridine)]; cyclohexyl BrettPhos in N,N-dimethyl-formamide
T=150°C; 24 h;
参考文献
Nishihara, Yasushi; Ogawa, Daisuke; Noyori, Shintaro; Iwasaki, Masayuki
Chemistry Letters, 2012 , vol. 41, # 11 p. 1503 - 1505
反应条件
copper(l) iodide; [PdCl2(2,2'-bipyridine)]; cyclohexyl BrettPhos in N,N-dimethyl-formamide
T=120°C; 24 h;
参考文献
Nishihara, Yasushi; Ogawa, Daisuke; Noyori, Shintaro; Iwasaki, Masayuki
Chemistry Letters, 2012 , vol. 41, # 11 p. 1503 - 1505
反应条件
copper(l) iodide; [PdCl2(2,2'-bipyridine)]; cyclohexyl BrettPhos in N,N-dimethyl-formamide
T=120°C; 24 h;
参考文献
Nishihara, Yasushi; Ogawa, Daisuke; Noyori, Shintaro; Iwasaki, Masayuki
Chemistry Letters, 2012 , vol. 41, # 11 p. 1503 - 1505
反应条件
copper(l) iodide; [PdCl2(2,2'-bipyridine)]; cyclohexyl BrettPhos in N,N-dimethyl-formamide
T=120°C; 24 h;
参考文献
Nishihara, Yasushi; Ogawa, Daisuke; Noyori, Shintaro; Iwasaki, Masayuki
Chemistry Letters, 2012 , vol. 41, # 11 p. 1503 - 1505
反应条件
potassium carbonate; chlorobenzene in ethanol
T=60°C; Sonogashira Cross-Coupling; 18 h; Green chemistry; Time;
参考文献
Wang, Hu; Li, Li; Bai, Xing-Feng; Deng, Wen-Hui; Zheng, Zhan-Jiang; Yang, Ke-Fang; Xu, Li-Wen
Green Chemistry, 2013 , vol. 15, # 9 p. 2349 - 2355
反应条件
caesium carbonate; polymer-supported N-heterocyclic carbene palladium complex in water; N,N-dimethyl-formamide
T=80°C; Sonogashira coupling; Product distribution; Further Variations:ReagentsTemperatures;
参考文献
Kim, Jong-Ho; Lee, Dong-Ho; Jun, Bong-Hyun; Lee, Yoon-Sik
Tetrahedron Letters, 2007 , vol. 48, # 40 p. 7079 - 7084
