3,4'-二甲基-1,1'-联苯合成路线 （共 62 条）
反应条件
1-isopropyl-3-methyl-2,4-diphenylimidazolium iodide; palladium diacetate; caesium carbonate in 1,4-dioxane
T=80°C; Suzuki-Miyaura coupling; 24 h; Inert atmosphere;
参考文献
Xu, Xiangya; Xu, Baochang; Li, Yongxin; Hong, Soon Hyeok
Organometallics, 2010 , vol. 29, # 23 p. 6343 - 6349
反应条件
5-palladium/activated carbon; potassium carbonate in ethanol; water
T=50°C; Suzuki-Miyaura coupling; 24 h;
参考文献
LeBlond, Carl R.; Butler, Kaycie M.; Ferrington, Marc W.; Browe, Matthew A.
Synthetic Communications, 2009 , vol. 39, # 4 p. 636 - 640
反应条件
1: 3-methylphenylmagnesium chloride With zinc(II) chloride in tetrahydrofuran
T=0 - 20°C;
2: p-toluenesulfonyl chloride With Pd0(tris(tert-butyl)phosphine)2 in tetrahydrofuran
Negishi reaction; Heating;
参考文献
Dubbaka, Srinivas Reddy; Vogel, Pierre
Tetrahedron Letters, 2006 , vol. 47, # 20 p. 3345 - 3348
反应条件
sodium hydroxide; hydrazine hydrate in diethylene glycol
1.) reflux, 6 h, 2.) 200 deg C, 30 min;
参考文献
Rao, M. Suresh Chander; Rao, G. S. Krishna
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1988 , vol. 27, # 1-12 p. 213 - 216
反应条件
tris-(dibenzylideneacetone)dipalladium(0); copper(I) bromide dimethylsulfide complex; trifuran-2-yl-phosphane in tetrahydrofuran
Stille coupling; Heating;
参考文献
Dubbaka, Srinivas Reddy; Vogel, Pierre
Journal of the American Chemical Society, 2003 , vol. 125, # 50 p. 15292 - 15293
反应条件
in tetrahydrofuran
T=20°C; Substitution; 3 h;
参考文献
Watanabe, Shin-Ichi; Yamamoto, Keiichirou; Itagaki, Yukiko; Iwamura, Tatsunori; Iwama, Tetsuo; Kataoka, Tadashi
Tetrahedron, 2000 , vol. 56, # 6 p. 855 - 863
反应条件
dimethoxy sulfoxide in diethyl ether
2 h; Heating;
参考文献
Hara, Yoshinori; Matsuda, Minoru
Phosphorus and Sulfur and the Related Elements, 1983 , vol. 16, p. 211 - 222
反应条件
bis-(4-methylphenyl)-sulfoxide in diethyl ether
2 h; Heating;
参考文献
Hara, Yoshinori; Matsuda, Minoru
Phosphorus and Sulfur and the Related Elements, 1983 , vol. 16, p. 211 - 222
反应条件
trichlorophosphate
1.) 30 deg C, 30 min; 2.) 6 h;
参考文献
Suresh Chander Rao, M.; Krishna Rao, G. S.
Synthesis, 1987 , # 3 p. 231 - 233
反应条件
1: 100 percent / aq. NaOH / toluene
2: 80 percent / 1,1'-bis(diphenylphosphino)ferrocene dichloropalladium / toluene / 24 h / Heating
View Scheme
参考文献
Cammidge, Andrew N.; Goddard, Victoria H. M.; Gopee, Hemant; Harrison, Nicola L.; Hughes, David L.; Schubert, Christopher J.; Sutton, Benjamin M.; Watts, Gary L.; Whitehead, Andrew J.
Organic Letters, 2006 , vol. 8, # 18 p. 4071 - 4074
