3-氨基-9H-吡啶并[3,4-b]吲哚合成路线 （共 15 条）
反应条件
1: potassium permanganate / N,N-dimethyl-formamide / 24 h / 20 °C
2: hydrazine hydrate / methanol / Reflux
3: hydrogenchloride; sodium nitrite / water / 0 °C
4: hydrogenchloride / water / 100 °C
View Scheme
参考文献
Wang, Yue; Jin, Qiaomei; Lin, Guowu; Yang, Taotao; Wang, Zhanwei; Lu, Yi; Tang, Yimin; Liu, Lifang; Lu, Tao
Chemical and Pharmaceutical Bulletin, 2012 , vol. 60, # 4 p. 435 - 441
反应条件
1: trichloroisocyanuric acid; triethylamine / N,N-dimethyl-formamide / 2 h / -20 - 0 °C / Inert atmosphere
2: hydrazine hydrate / pentan-1-ol / 7 h / Reflux; Inert atmosphere
3: hydrogenchloride; sodium nitrite / water / 2 h / 0 °C / Inert atmosphere
4: acetic acid / water / 1 h / Reflux
View Scheme
参考文献
Ikeda, Reiko; Kimura, Takanori; Tsutsumi, Tatsuya; Tamura, Syunsuke; Sakai, Norio; Konakahara, Takeo
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 10 p. 3506 - 3515
反应条件
1: thionyl chloride / 24 h / 0 °C / Reflux; Inert atmosphere
2: trichloroisocyanuric acid; triethylamine / N,N-dimethyl-formamide / 2 h / -20 - 0 °C / Inert atmosphere
3: hydrazine hydrate / pentan-1-ol / 7 h / Reflux; Inert atmosphere
4: hydrogenchloride; sodium nitrite / water / 2 h / 0 °C / Inert atmosphere
5: acetic acid / water / 1 h / Reflux
View Scheme
参考文献
Ikeda, Reiko; Kimura, Takanori; Tsutsumi, Tatsuya; Tamura, Syunsuke; Sakai, Norio; Konakahara, Takeo
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 10 p. 3506 - 3515
反应条件
T=400 - 500°C; 1 h; Further byproducts given;
参考文献
Tada; Saeki; Oikawa
Bulletin of the Chemical Society of Japan, 1983 , vol. 56, # 5 p. 1450 - 1454
反应条件
1: 60 percent / pyridine / 1 h / Ambient temperature
2: 40 percent / LiAlH4 / tetrahydrofuran / 1.5 h / Heating
View Scheme
参考文献
Ikeda, Reiko; Iwaki, Toshie; Iida, Tomoko; Okabayashi, Takasumi; Nishi, Eishiro; Kurosawa, Masaki; Sakai, Norio; Konakahara, Takeo
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 2 p. 636 - 646
