N-(2-羟基丙基)-2-[2-(2-羟基丙基氨基甲酰)苯基]二巯基苯甲酰胺合成路线 （共 5 条）
反应条件
in 1,4-dioxane
1.) 10 deg C, 1 h; 2.) room temp., 2 h;
参考文献
Yamada; Niino; Hashimoto; Shuto; Nakamizo; Kubo; Ono; Murayama
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 3 p. 1214 - 1220
反应条件
1: pyridine, thionyl chloride / toluene / Heating
2: 80.1 percent / dioxane / 1.) 10 deg C, 1 h; 2.) room temp., 2 h
View Scheme
参考文献
Yamada; Niino; Hashimoto; Shuto; Nakamizo; Kubo; Ono; Murayama
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 3 p. 1214 - 1220
反应条件
pyridine
1.) dichloromethane, 30 min, 2.) 2 h; Yield given. Multistep reaction;
参考文献
Okachi, Ryo; Niino, Hideki; Kitaura, Kozo; Mineura, Kazuyuki; Nakamizo, Yoshinobu; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1772 - 1779
反应条件
pyridine
1.) dichloromethane, RT, 30 min, 2.) RT, 2 h; Yield given. Multistep reaction;
参考文献
Okachi, Ryo; Niino, Hideki; Kitaura, Kozo; Mineura, Kazuyuki; Nakamizo, Yoshinobu; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1772 - 1779
反应条件
1: bromine / CH2Cl2
2: triethylamine / CH2Cl2 / 0.33 h / 50 °C
View Scheme
参考文献
Okachi, Ryo; Niino, Hideki; Kitaura, Kozo; Mineura, Kazuyuki; Nakamizo, Yoshinobu; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1772 - 1779
