(4-氨基-2-硝基-苯基)-氨基甲酸乙酯合成路线 （共 7 条）
反应条件
sodium tetrahydroborate in water; isopropyl alcohol T=20°C; SolventTemperatureTime;
参考文献
WO2013/11518 A1, ;
Page/Page column 43-44 ;
反应条件
1: ethanol / 20 - 65 °C 2: sodium tetrahydroborate / isopropyl alcohol; water / 0 - 30 °C View Scheme
反应条件
1: sodium tetrahydroborate / isopropyl alcohol; water / 20 °C 2: hydrogen; palladium 10 on activated carbon; ammonia / methanol / 25 - 30 °C / 2250.23 - 3000.3 Torr / |Inert atmosphere; |Autoclave View Scheme
参考文献
ARCH PHARMALABS LIMITED; MANDAL, Arun Kanti; RANBHAN, Kamlesh Jayantilal; SAXENA, Sudhanshu; GAIKWAD, Sanjay Ramrao; SARJEKAR, Pushpalata Balkrishna
Patent: WO2013/11518 A1, 2013 ;
反应条件
methylamine in water; isopropyl alcohol
T=60 - 65°C; 2 h; ConcentrationReagent/catalystSolventTemperatureTime;
参考文献
ARCH PHARMALABS LIMITED; MANDAL, Arun Kanti; RANBHAN, Kamlesh Jayantilal; SAXENA, Sudhanshu; GAIKWAD, Sanjay Ramrao; SARJEKAR, Pushpalata Balkrishna
Patent: WO2013/11518 A1, 2013 ;
Location in patent: Page/Page column 39-40 ;
反应条件
sulfuric acid; nitric acid in water
T=-5 - 0°C; 0.5 h; Inert atmosphere;
参考文献
Dipharma Francis S.r.l.; Attolino, Emanuele; Rossi, Roberto; Artico, Marco
Patent: EP2730560 A1, 2014 ;
Location in patent: Paragraph 0033 ;
反应条件
1: nitric acid / acetic acid / 20 - 105 °C / |Inert atmosphere
2: methylamine / isopropyl alcohol; water / 2 h / 60 - 65 °C
View Scheme
参考文献
ARCH PHARMALABS LIMITED; MANDAL, Arun Kanti; RANBHAN, Kamlesh Jayantilal; SAXENA, Sudhanshu; GAIKWAD, Sanjay Ramrao; SARJEKAR, Pushpalata Balkrishna
Patent: WO2013/11518 A1, 2013 ;
反应条件
1: ammonium formate; 5 palladium on charcoal / tetrahydrofuran; water / 24 h / 50 °C / |Inert atmosphere
2: sulfuric acid; nitric acid / water / 0.5 h / -5 - 0 °C / |Inert atmosphere
View Scheme
参考文献
Dipharma Francis S.r.l.; Attolino, Emanuele; Rossi, Roberto; Artico, Marco
Patent: EP2730560 A1, 2014 ;
