2-氨基-6-甲氧基-3-硝酸吡啶合成路线 （共 17 条）
反应条件
1: ammonium hydroxide / 5 h / 50 °C 2: ethanol / 16 h / -15 - 20 °C View Scheme
反应条件
1: sulfuric acid; nitric acid / -15 - 150 °C 2: ammonium hydroxide / 5 h / 50 °C 3: ethanol / 16 h / -15 - 20 °C View Scheme
反应条件
1: HBr; AcOH / 60 °C 2: POCl3 / 100 °C View Scheme
参考文献
McClure, Kelly J.; Huang, Liming; Arienti, Kristen L.; Axe, Frank U.; Brunmark, Anders; Blevitt, Jon; Guy Breitenbucher
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 7 p. 1924 - 1928
反应条件
P2O5; hydrogen bromide; acetic acid in toluene
参考文献
Arienti, Kristen L.; Axe, Frank U.; Breitenbucher, J. Guy; Huang, Liming; Lee, Alice; McClure, Kelly J.
Patent: US2003/176438 A1, 2003 ;
反应条件
hydrogen; palladium 10 on activated carbon T=25°C; 6 h;
参考文献
PURDUE PHARMA L.P.; SHIONOGI and CO., LTD.
Patent: WO2008/89201 A2, 2008 ;
Location in patent: Page/Page column 254 ;
WO 2008/089201 A2
反应条件
N-iodo-succinimide; acetic acid
T=20°C; 21.5 h;
参考文献
EISAI CO., LTD.
Patent: WO2005/103049 A1, 2005 ;
Location in patent: Page/Page column 103 ;
反应条件
1: hydrogenchloride; tin(ll) chloride / 5 h / 50 °C
2: methanol / 20 °C
View Scheme
参考文献
VITAS PHARMA RESEARCH PVT LTD; ALAPATI, Chandrasekhar; BANERJEE, Ankita; RANGARAJAN, Radha; KUMAR, Rajinder
Patent: WO2014/57415 A2, 2014 ;
