3-苯基-3-(三氟甲基)-3H-双吖丙啶合成路线 （共 12 条）
反应条件
ammonia in dichloromethane
参考文献
WO2006/18729 A1, ;
Page/Page column 13-14 ;
反应条件
1: 86 percent / CH2Cl2 / 0 °C / Irradiation 2: 91 percent / H2O, B(OH)3 / ethanol / 8 h / 80 °C View Scheme
参考文献
Barton, Derek H.R.; Jaszberenyi, Joseph Cs.; Theodorakis, Emmanouil A.
Journal of the American Chemical Society, 1992 , vol. 114, # 14 p. 5904 - 5905
反应条件
1: 86 percent / CH2Cl2 / 0 °C / Irradiation 2: H2O, B(OH)3 / ethanol / 8 h / 80 °C View Scheme
参考文献
Barton, Derek H. R.; Jaszberenyi, Joseph Cs.; Theodorakis, Emmanouil A.; Reibenspies
Journal of the American Chemical Society, 1993 , vol. 115, # 18 p. 8050 - 8059
反应条件
1: 1.) Tl(CO2CF3)3, TFA; 2.) MgO, LiCl; 3.) 1N NaOH / 2.) PdCl2 / 1.) 75 deg C, 24 h; 2.) r.t., 24 h; 3.) MeOH, r.t., 2 h 2: 95 percent / DCC / CH2Cl2 / 2 h View Scheme
参考文献
Heterocycles, , vol. 43, # 3 p. 519 - 522
反应条件
1: 80 percent / TiCl4 / various solvent(s) / 1 h / 20 °C 2: 100 percent / NaBH4 / ethanol / 4 h / 20 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 128, # 47 p. 15092 - 15093
反应条件
sodium hydroxide; magnesium oxide; trifluoroacetic acid; lithium chloride; Tl(OCOCF3)3; palladium dichloride 1.) 75 deg C, 24 h; 2.) r.t., 24 h; 3.) MeOH, r.t., 2 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Hatanaka, Yasumaru; Nakamura, Norio; Wakabayashi, Miwa; Fujioka, Toshiyuki; Kikuchi, Tohru
Heterocycles, 1996 , vol. 43, # 3 p. 519 - 522
反应条件
titanium tetrachloride in various solvent(s) T=20°C; 1 h;
参考文献
Nakashima, Hiroyuki; Hashimoto, Makoto; Sadakane, Yutaka; Tomohiro, Takenori; Hatanaka, Yasumaru
Journal of the American Chemical Society, 2006 , vol. 128, # 47 p. 15092 - 15093
反应条件
in solid matrix T=-261.2°C; Irradiation;
参考文献
Mal'tsev, A. K.; Zuev, P. S.; Nefedov, O. M.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1987 , vol. 36, # 2 p. 425 - 426
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1987 , # 2 p. 463 - 464
反应条件
in dichloromethane T=0 - 5°C; Irradiation;
参考文献
Barton, Derek H.R.; Jaszberenyi, Joseph Cs.; Theodorakis, Emmanouil A.
Journal of the American Chemical Society, 1992 , vol. 114, # 14 p. 5904 - 5905
反应条件
trifluorormethanesulfonic acid
T=-40°C; 1 h;
参考文献
Nakashima, Hiroyuki; Hashimoto, Makoto; Sadakane, Yutaka; Tomohiro, Takenori; Hatanaka, Yasumaru
Journal of the American Chemical Society, 2006 , vol. 128, # 47 p. 15092 - 15093
