1-methyl-piperazine in epichlorohydrin

1: SOCl2, DMF / CH2Cl2 / 3 h / Ambient temperature 2: NH3 / CH2Cl2; diethyl ether / -20 °C 3: 83 percent / trifluoroacetic acid anhydride, pyridine / 2 h / 0 °C 4: 82 percent / ammonium formate / 5percent Pd/C / methanol / a) RT, 1 h, b) reflux 5: 75 percent / morpholine / 2.5 h / Heating View Scheme

morpholine 2.5 h; Heating;

triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran 6 h; Ambient temperature; Yield given;