4-氯-3-甲氧基甲苯合成路线

参考文献

SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/154271 A1, 2008 ;
Location in patent: Page/Page column 47-48 ;

参考文献

EXELIXIS, INC.; BOLLU, Venkataiah; BOREN, Brant, Clayton; DALGARD, Jackline, Eve; FLATT, Brenton, T.; HAQ, Nadia; HUDSON, Sarah; MOHAN, Raju; MORRISSEY, Michael; PRATT, Benjamin; WANG, Tie-lin
Patent: WO2010/93845 A1, 2010 ;
Location in patent: Page/Page column 136-137 ;
WO 2010/093845 A1

77-78-1硫酸二甲酯

73909-16-74-氯-3-甲氧基甲苯

参考文献

SMITHKLINE BEECHAM CORPORATION
Patent: WO2005/82890 A1, 2005 ;
Location in patent: Page/Page column 87-88 ;
WO 2005/082890 A1

615-74-72-氯-5-甲酚

73909-16-74-氯-3-甲氧基甲苯

参考文献

Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;

615-74-72-氯-5-甲酚+

18107-18-1三甲基硅烷化重氮甲烷

73909-16-74-氯-3-甲氧基甲苯

参考文献

SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/154271 A1, 2008 ;
Location in patent: Page/Page column 47 ;

615-74-72-氯-5-甲酚+

75-03-6碘乙烷

3031-86-5+

73909-16-74-氯-3-甲氧基甲苯

参考文献

US6384080 B1, ;

93-51-62-甲氧基-4-甲基苯酚

73909-16-74-氯-3-甲氧基甲苯

参考文献

Justus Liebigs Annalen der Chemie, , vol. 151, p. 115

73909-16-74-氯-3-甲氧基甲苯

110463-12-2

参考文献

Akita; Matsukura; Oishi
Tetrahedron Letters, 1986 , vol. 27, # 45 p. 5397 - 5400

73909-16-74-氯-3-甲氧基甲苯+

75-36-5乙酰氯

103039-12-9

参考文献

SCHERING CORPORATION
Patent: WO2006/19768 A1, 2006 ;
Location in patent: Page/Page column 156-157 ;
WO 2006/019768 A1

73909-16-74-氯-3-甲氧基甲苯

23219-33-24-氯-3-羟基邻氨基苯甲酸

参考文献

Melikian; Boigegrain; Kan; Soubrie
European Journal of Medicinal Chemistry, 1990 , vol. 25, # 3 p. 267 - 270