1: With di-isopropyl azodicarboxylate; N-hydroxyphthalimide resin; triphenylphosphine; 1H-imidazole in dichloromethane T=20°C; Mitsunobu reaction; 24 h; 2: With methylamine in methanol; chloroform T=20°C; 2 h;

hydrazine hydrate in methanol 4 h; Heating;

2: aqueous hydrochloric acid View Scheme

sodium hydroxide; acetone-oxime

in tetrahydrofuran