7,8-二甲氧基-1,3-二氢-2H-3-苯并氮杂卓-2-酮合成路线 （共 13 条）
反应条件
hydrogenchloride; acetic acid in water T=25°C; 17 h;
参考文献
KRKA, D. D., NOVO MESTO; BOSE, Prosenjit; SIRIPALLI, Udaya Bhaskara Rao; KANDADAI, Appan Srinivas
Patent: WO2010/72409 A1, 2010 ;
Location in patent: Page/Page column 17-18 ;
反应条件
1: 81 percent / thionyl chloride / CH2Cl2 / 1 h / Heating 2: triethylamine / CH2Cl2 / 1 h / Ambient temperature 3: 75 percent / glacial acetic acid, conc. HCl / 17 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 5 p. 1496 - 1504
反应条件
1: triethylamine / CH2Cl2 / 1 h / Ambient temperature 2: 75 percent / glacial acetic acid, conc. HCl / 17 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 5 p. 1496 - 1504
反应条件
in dimethyl sulfoxide; acetone
反应条件
in dimethyl sulfoxide; acetone
反应条件
1.1: potassium tert-butylate / N,N-dimethyl-formamide / 25 °C 1.2: 1.5 h / 40 °C 2.1: sodium iodide / acetone / 20 h / 55 - 58 °C 3.1: potassium carbonate / acetone / 3 h / 55 - 58 °C 4.1: acetic acid; palladium(II) oxide hydrate; hydrogen / 3 h / 25 - 30 °C / 2250.23 - 3000.3 Torr View Scheme
参考文献
GLENMARK PHARMACEUTICALS LIMITED; GLENMARK GENERICS LIMITED; BHIRUD, Shekhar Bhaskar; BHUSHAN, Kumar Hari; ZOPE, Sunil Sudhakar; PATIL, Dipak Vinayak; DHEBADE, Pramod Amrutrao; CHAND, Prem
Patent: WO2014/102827 A1, 2014 ;
反应条件
1.1: potassium tert-butylate / N,N-dimethyl-formamide / 25 °C 1.2: 1.5 h / 40 °C 2.1: sodium iodide / acetone / 20 h / 55 - 58 °C View Scheme
反应条件
palladium/charcoal in dichloromethane; acetic acid
参考文献
Dr. Karl Thomae Gesellschaft mit beschrankter Haftung
Patent: US4490369 A1, 1984 ;
反应条件
1: 2,3-dihydro-7,8-dimethoxy-2-oxo-1H-3-benzazepine With potassium tert-butylate in dimethyl sulfoxide
T=20°C; 0.5 h;
2: 3-chloro-N-{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}-N-methyl-1-propanamine in dimethyl sulfoxide
T=20°C;
参考文献
LES LABORATOIRES SERVIER
Patent: US2012/172589 A1, 2012 ;
Location in patent: Page/Page column 3 ;
