1-环己基-5-(4-氯丁基)-四氮唑合成路线 （共 7 条）
反应条件
1: With phosphorus pentachloride in toluene T=20°C; 3 h; 2: With trimethylsilylazide T=20°C; 16 h;
参考文献
DIPHARMA S.P.A.
Patent: WO2005/19204 A1, 2005 ;
Location in patent: Page/Page column 5-6 ;
反应条件
hydrogen azide in ethyl acetate; benzene
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in ethanol T=75 - 80°C;
参考文献
WO2006/22488 A1, ;
Page/Page column 3 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide T=80°C; 7 h;
参考文献
Heterocycles, , vol. 78, # 1 p. 189 - 195
反应条件
sodium hydroxide; potassium carbonate; sodium sulfite in water; isopropyl alcohol 6 h; Heating / reflux;
参考文献
OTSUKA PHARMACEUTICAL CO., LTD.
Patent: EP1489080 A1, 2004 ;
Location in patent: Page 6 ;
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in ethanol T=75 - 80°C;
参考文献
YUHAN CORPORATION
Patent: WO2006/22488 A1, 2006 ;
Location in patent: Page/Page column 3 ;
反应条件
1: 6-hydroxy-1,2,3,4-tetrahydro-2-quinolinone With 1,8-diazabicyclo[5.4.0]undec-7-ene in ethanol 6.5 h; Heating / refluxMolecular sieve; 2: 1-cyclohexyl-5-(4-chlorobutyl)-1,2,3,4-tetrazole in ethanol 6.5 h; Heating / reflux; Product distribution / selectivity;
参考文献
Naddaka, Vladimir; Davidi, Guy; Saeed, Shady; Arad, Oded; Kaspi, Joseph
Patent: US2005/222202 A1, 2005 ;
Location in patent: Page/Page column 5; 9 ;
