1-(3-叠氮基-2,3-二脱氧-beta-D-苏式-呋喃戊糖基)-5-甲基-2,4(1H,3H)-嘧啶二酮合成路线 （共 9 条）
反应条件
water; acetic acid
T=120°C; 0.333333 h;
参考文献
Dong, Guimin; Zhang, Liangren; Zhang, Lihe
Helvetica Chimica Acta, 2003 , vol. 86, # 10 p. 3516 - 3524
反应条件
trimethylsilyl trifluoromethanesulfonate in acetonitrile
T=-30 - 20°C; Further byproducts given;
参考文献
Gauthier, Christine; Ramondenc, Yvan; Ple, Gerard
Tetrahedron, 2001 , vol. 57, # 35 p. 7513 - 7517
反应条件
1: 71 percent / NaN3 / dimethylformamide / 4 h / 100 °C
2: 83 percent / AcOH; H2O / 0.33 h / 120 °C
View Scheme
参考文献
Dong, Guimin; Zhang, Liangren; Zhang, Lihe
Helvetica Chimica Acta, 2003 , vol. 86, # 10 p. 3516 - 3524
反应条件
1: 53 percent / NaHCO3 / methanol / 0.75 h / Ambient temperature
2: 80 percent AcOH / 24 h / Ambient temperature
3: pyridine / CH2Cl2 / 1) 0 deg C, 1 h 2) r.t. 20 h
4: CF3SO3SiMe3 / MeCN 1) -30 deg C, 30 min 2) 0 deg C, 60 min
5: MeNH2 / methanol / 24 h / Ambient temperature
View Scheme
参考文献
Wengel; Pedersen
Synthesis, 1991 , # 6 p. 451 - 454
反应条件
1: 99 percent / NaN3 / acetic acid / 3 h / 20 °C
2: 65 percent / TiCl4 / CH2Cl2 / 0 - 20 °C
3: 13 percent / TMSOTf / acetonitrile / -30 - 20 °C
View Scheme
参考文献
Gauthier, Christine; Ramondenc, Yvan; Ple, Gerard
Tetrahedron, 2001 , vol. 57, # 35 p. 7513 - 7517
反应条件
1: 65 percent / TiCl4 / CH2Cl2 / 0 - 20 °C
2: 13 percent / TMSOTf / acetonitrile / -30 - 20 °C
View Scheme
参考文献
Gauthier, Christine; Ramondenc, Yvan; Ple, Gerard
Tetrahedron, 2001 , vol. 57, # 35 p. 7513 - 7517
反应条件
1: 80 percent AcOH / 24 h / Ambient temperature
2: pyridine / CH2Cl2 / 1) 0 deg C, 1 h 2) r.t. 20 h
3: CF3SO3SiMe3 / MeCN 1) -30 deg C, 30 min 2) 0 deg C, 60 min
4: MeNH2 / methanol / 24 h / Ambient temperature
View Scheme
参考文献
Wengel; Pedersen
Synthesis, 1991 , # 6 p. 451 - 454
反应条件
1: CF3SO3SiMe3 / MeCN 1) -30 deg C, 30 min 2) 0 deg C, 60 min
2: MeNH2 / methanol / 24 h / Ambient temperature
View Scheme
参考文献
Wengel; Pedersen
Synthesis, 1991 , # 6 p. 451 - 454
反应条件
1: triethylamine / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere
2: lithium azide / N,N-dimethyl-formamide / 8 h / 100 °C / Inert atmosphere
3: acetic acid / water / 20 °C / Inert atmosphere
View Scheme
参考文献
Sun, Jingbo; Liu, Xinyu; Li, Hongming; Duan, Ronghui; Wu, Jinchang
Helvetica Chimica Acta, 2012 , vol. 95, # 5 p. 772 - 779
