2,4-二氨基-6-羟甲基蝶啶盐酸盐合成路线 (共 7 条)
反应条件
ammonium chloride in water
参考文献
Research Corporation
Patent: US4820706 A1, 1989 ;
反应条件
oxygen; dl-cysteine hydrochloride; ammonium chloride in water 36 h;
参考文献
Boyle, Peter H.; Pfleiderer, Wolfgang
Chemische Berichte, 1980 , vol. 113, # 4 p. 1514 - 1523
反应条件
ammonium hydroxide; L-cysteine monohydrochloride powder; oxygen; ammonium chloride; BaCl2 1.) H2O, 90 deg C, 15 min, 2.) H2O, RT, 45 h; Yield given. Multistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 5 p. 660 - 667
反应条件
ammonium hydroxide in water Heating;
参考文献
Boyle, Peter H.; Pfleiderer, Wolfgang
Chemische Berichte, 1980 , vol. 113, # 4 p. 1514 - 1523
反应条件
ammonium hydroxide; hydrogen bromide; bromine; triphenylphosphine in ethanol; N,N-dimethyl acetamide; water; acetic acid; benzene
参考文献
Research Corporation
Patent: US4820706 A1, 1989 ;
反应条件
1: 2,4-diamino-6-(hydroxymethyl)pteridine hydrochloride With bromine; triphenylphosphine in isobutyramide T=0 - 20°C; 20 h; 2: p-(N-methyl)-amino-benzoic acid With N-ethyl-N,N-diisopropylamine in isobutyramide T=60 - 70°C; 24 h; 3: With hydrogenchloride; sodium hydroxide more than 3 stages;
参考文献
GPC Biotech, Inc.
Patent: US7230101 B1, 2007 ;
Location in patent: Page/Page column 60; 79 ;
反应条件
hydrogen bromide; acetic acid in water
T=20°C; 96 h;
参考文献
Shi, Genbin; Shaw, Gary; Liang, Yu-He; Subburaman, Priadarsini; Li, Yue; Wu, Yan; Yan, Honggao; Ji, Xinhua
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 1 p. 47 - 57