乙基2-甲基-4-氧代-1H-喹啉-3-羧酸酯合成路线 （共 9 条）
反应条件
sodium hydride in N,N-dimethyl acetamide
T=120°C; 0.166667 h;
参考文献
Hayashi; Miwa; Ichikawa; Yoda; Miki; Ishii; Kono; Yasuzawa; Suzuki
Journal of medicinal chemistry, 1993 , vol. 36, # 5 p. 617 - 626
反应条件
in diphenylether
T=210 - 225°C; 0.5 h;
参考文献
Aritomi, Jiro; Ueda, Shozo; Nishimura, Haruki
Chemical & Pharmaceutical Bulletin, 1981 , vol. 29, # 12 p. 3712 - 3715
反应条件
1: pyridine / toluene / 2 h / Heating
2: 1.03 g / diphenyl ether / 1 h / 250 °C
View Scheme
参考文献
Hoeglund, Iisa P. J.; Silver, Satu; Engstroem, Mia T.; Salo, Harri; Tauber, Andrei; Kyyroenen, Hanna-Kaisa; Saarenketo, Pauli; Hoffren, Anna-Marja; Kokko, Kurt; Pohjanoksa, Katariina; Sallinen, Jukka; Savola, Juha-Matti; Wurster, Siegfried; Kallatsa, Oili A.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 21 p. 6351 - 6363
反应条件
1: 70 percent / Ac2O; ZnCl2 / 4 h / 140 °C
2: pyridine / toluene / 2 h / Heating
3: 1.03 g / diphenyl ether / 1 h / 250 °C
View Scheme
参考文献
Hoeglund, Iisa P. J.; Silver, Satu; Engstroem, Mia T.; Salo, Harri; Tauber, Andrei; Kyyroenen, Hanna-Kaisa; Saarenketo, Pauli; Hoffren, Anna-Marja; Kokko, Kurt; Pohjanoksa, Katariina; Sallinen, Jukka; Savola, Juha-Matti; Wurster, Siegfried; Kallatsa, Oili A.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 21 p. 6351 - 6363
反应条件
Erhitzen des Reaktionsprodukts in Mineraloel oder mit H2SO4 und Acetanhydrid;
参考文献
Coutts; Wibberley
Journal of the Chemical Society, 1962 , p. 2518,2519
反应条件
palladium on activated charcoal; ethanol; cyclohexene
参考文献
Coutts; Wibberley
Journal of the Chemical Society, 1962 , p. 2518,2519
反应条件
potassium hydroxide in ethanol; water
Reflux;
参考文献
Mai, Antonello; Rotili, Dante; Tarantino, Domenico; Nebbioso, Angela; Castellano, Sabrina; Sbardella, Gianluca; Tini, Marc; Altucci, Lucia
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 4 p. 1132 - 1135
反应条件
in acetic acid
T=135°C; 1 h;
参考文献
Sukhova, N. M.; Lapina, T. V.; Lidak, M. Yu.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1983 , vol. 19, # 11 p. 1207 - 1210
Khimiya Geterotsiklicheskikh Soedinenii, 1983 , # 11 p. 1521 - 1523
反应条件
trichlorophosphate
T=110°C; 0.333333 h; Inert atmosphere;
参考文献
Goncalves, Victor; Brannigan, James A.; Whalley, David; Ansell, Keith H.; Saxty, Barbara; Holder, Anthony A.; Wilkinson, Anthony J.; Tate, Edward W.; Leatherbarrow, Robin J.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 7 p. 3578 - 3582
