(4,6-DICHLOROPYRIDIN-3-YL)METHANOL合成路线 （共 8 条）
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=0 - 40°C; 0.25 h; 2: With sodium hydroxide; water in tetrahydrofuran
参考文献
Zhu, Yuanming; Loso, Michael R.; Nugent, Benjamin M.; Huang, Jim X.; Rogers, Richard B.
Patent: US2008/108667 A1, 2008 ;
Location in patent: Page/Page column 13 ;
反应条件
methanol; sodium tetrahydroborate in tetrahydrofuran 2 h;
参考文献
MERCK SHARP and DOHME CORP.; LYCERA CORPORATION; AICHER, Thomas; BARR, Kenneth; LAPOINTE, Blair; SIMOV, Vladimir; STEIN, Karin; THOMAS, William; TOOGOOD, Peter; VAN HUIS, Chad; WHITE, Catherine
Patent: WO2013/169704 A2, 2013 ;
Location in patent: Paragraph 0230 ;
反应条件
hydrogenchloride; nitrogen in tetrahydrofuran
反应条件
thionyl chloride in dichloromethane T=0 - 20°C; 0.25 h;
参考文献
Gavai, Ashvinikumar V.; Norris, Derek J.; Han, Wen-Ching; Vite, Gregory D.; Fink, Brian E.; Tokarski, John S.
Patent: US2005/192310 A1, 2005 ;
Location in patent: Page/Page column 32 ;
反应条件
manganese(IV) oxide in chloroform T=75°C; 12 h;
参考文献
MERCK SHARP and DOHME CORP.; LYCERA CORPORATION; AICHER, Thomas; BARR, Kenneth; LAPOINTE, Blair; SIMOV, Vladimir; STEIN, Karin; THOMAS, William; TOOGOOD, Peter; VAN HUIS, Chad; WHITE, Catherine
Patent: WO2013/169704 A2, 2013 ;
Location in patent: Paragraph 0231 ;
反应条件
1: manganese(IV) oxide / chloroform / 12 h / 75 °C 2: hydrazine; N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 4 h / 80 °C View Scheme
参考文献
MERCK SHARP and DOHME CORP.; LYCERA CORPORATION; AICHER, Thomas; BARR, Kenneth; LAPOINTE, Blair; SIMOV, Vladimir; STEIN, Karin; THOMAS, William; TOOGOOD, Peter; VAN HUIS, Chad; WHITE, Catherine
Patent: WO2013/169704 A2, 2013 ;
反应条件
1: With sulfuryl dichloride in tetrachloromethane
Heating / reflux;
2: With sodium hydrogencarbonate in water
pH=8;
参考文献
KALYSPSYS, INC.; NOBLE, Stewart A.; OSHIRO, Guy; MALECHA, James W.; ZHAO, Cunxiang; ROBINSON, Carmen K. M.; DURON, Sergio G.; SERTIC, Michael; LINDSTROM, Andrew; SHIAU, Andrew; BAYNE, Christopher; KAHRAMAN, Mehmet; LOU, Boliang; GOVEK, Steven
Patent: WO2006/55187 A1, 2006 ;
Location in patent: Page/Page column 94-95 ;
WO 2006/055187 A1
