反应条件
1: 1.) s-BuLi, TMEDA / 1.) THF, cyclohexane, -90 deg C, 1 h, 2.) THF, cyclohexane, -80 deg C, 10 min 2: 1.) s-BuLi, TMEDA / 1.) THF, cyclohexane, -90 deg C, 1 h, 2.) THF, cyclohexane, -80 deg C, 10 min 3: ClSO3H / 1.5 h / 125 °C 4: aq. Na2SO3, aq. NaOH / 3 h / 15 - 20 °C 5: a) aq. NaOH, b) K2CO3 / dimethylformamide / 5 h / Heating View Scheme
参考文献
Baumgarth, Manfred; Beier, Norbert; Gericke, Rolf
Journal of Medicinal Chemistry, 1997 , vol. 40, # 13 p. 2017 - 2034
