反应条件
1: 1.) s-BuLi, TMEDA / 1.) THF, cyclohexane, -90 deg C, 1 h, 2.) THF, cyclohexane, -80 deg C, 10 min 2: ClSO3H / 6 h / 135 - 140 °C 3: aq. Na2SO3, aq. NaOH / 15 - 20 °C 4: aq. NaOH / methanol / 30 h / Heating 5: 88 percent / 4 h / 160 °C 6: 92 percent / H2 / 10percent Pd/C / methanol / 3 h / 45 °C / 760 Torr 7: 93 percent / HCl / 20 h / Heating View Scheme
参考文献
Baumgarth, Manfred; Beier, Norbert; Gericke, Rolf
Journal of Medicinal Chemistry, 1997 , vol. 40, # 13 p. 2017 - 2034
