1: D,L-2-amino-4-pentenoic acid; di-tert-butyl dicarbonate With sodium hydroxide in 1,4-dioxane; water T=0°C; 16 h; 2: With hydrogenchloride in 1,4-dioxane; water pH=2; 3: methyl iodide With potassium carbonate more than 3 stages;
参考文献
THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC
Patent: WO2006/55725 A2, 2006 ;
Location in patent: Page/Page column 204-205 ;
WO 2006/055725 A2