1: t-butyloxycarbonyl-L-serine With methanol; sodium hydride in tetrahydrofuran; mineral oil T=20°C; 1 h; 2: methyl iodide in tetrahydrofuran; methanol; mineral oil T=20°C; 38 h; 3: With citric acid in water pH=2;
参考文献
Takeda Pharmaceutical Company Limited
Patent: US2011/152273 A1, 2011 ;
Location in patent: Page/Page column 87 ;