1: ethyl bromide With magnesium in diethyl ether Reflux; 2: 2-pyridine carbonitrile in diethyl ether T=-0.16°C; Reflux; 3: With sulfuric acid; water in diethyl ether pH=Ca. 5;
参考文献
Perlovich, German L.; Kazachenko, Vladimir P.; Strakhova, Nadezda N.; Schaper, Klaus-J.; Raevsky, Oleg A.
Journal of Chemical and Engineering Data, 2013 , vol. 58, # 9 p. 2659 - 2667
1: ethyl bromide With iodine; magnesium in diethyl ether Inert atmosphere; 2: 4-fluorobenzenecarbonitrile in diethyl ether Grignard reaction; 6 h; Reflux; 3: With sulfuric acid; water in diethyl ether Heating;
参考文献
Lagoja, Irene; Pannecouque, Christophe; Griffioen, Gerard; Wera, Stefaan; Rojasdelaparra, Veronica Maria; Van Aerschot, Arthur
European Journal of Pharmaceutical Sciences, 2011 , vol. 43, # 5 p. 386 - 392