3-[(2-甲氧基-2-乙氧基)硫醇]甲基丙酸合成路线 （共 14 条）
反应条件
1: With TiCl3(i-PrO) in dichloromethane T=-10°C; 1.5 h; 2: With triethylamine in dichloromethane T=-10°C; 2 - 3 h; 3: With hydrogenchloride in dichloromethane; water T=-10 - 30°C;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2009/52138 A1, 2009 ;
Location in patent: Page/Page column 65-66 ;
反应条件
1: lithium methanolate / toluene / 18.5 h / 70 - 110 °C
2: sodium carbonate / water / 20 °C / |Darkness
3: water; hydrogenchloride; acetic acid / |Reflux
4: dichlorophenyl phosphine oxide / 135 - 165 °C
View Scheme
参考文献
CELLZOME LIMITED; LYNCH, Rosemary; CANSFIELD, Andrew David; HARDY, Daniel Paul; FEUTRILL, John Thomas; ADREGO, Rita; ELLARD, Katie; LADDUWAHETTY, Tammy
Patent: WO2013/50508 A1, 2013 ;
反应条件
sodium ethanolate
16 h; Heating;
参考文献
Shinkwin, Anne E.; Whish, William J. D.; Threadgill, Michael D.
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 2 p. 297 - 308
反应条件
lithium hydroxide hydrate; water in tetrahydrofuran; methanol
T=20°C;
参考文献
CALITHERA BIOSCIENCES INC.; LI, Jim; CHEN, Lijing; GOYAL, Bindu; LAIDIG, Guy; STANTON, Timothy, Friend; SJOGREN, Eric, Brian
Patent: WO2013/78123 A1, 2013 ;
Location in patent: Page/Page column 56; 57 ;
WO 2013/078123 A1
