3-羟基-2,2,4-三甲基-戊酸乙酯合成路线 (共 9 条)
反应条件
1: LiAlH4 2: aq. H2SO4 / Heating View Scheme
参考文献
Mazet,M.; Desmaison-Brut,M.
Bulletin de la Societe Chimique de France, 1971 , p. 2656 - 2662
反应条件
1: LiAlH4 2: aq. H2SO4 / Heating View Scheme
参考文献
Mazet,M.; Desmaison-Brut,M.
Bulletin de la Societe Chimique de France, 1971 , p. 2656 - 2662
反应条件
lithium aluminium tetrahydride
参考文献
Mazet,M.; Desmaison-Brut,M.
Bulletin de la Societe Chimique de France, 1971 , p. 2656 - 2662
反应条件
1: With bis(cyclopentadienyl)titanium dichloride; 2,3,5,6-tetramethyl-1,4-bis(trimethylsilyl)-1,4-diaza-2,5-cyclohexadiene in tetrahydrofuran
T=20°C; Reformatsky Reaction; 14 h; Inert atmosphere;
2: With hydrogenchloride in tetrahydrofuran; diethyl ether
Inert atmosphere;
参考文献
Saito, Teruhiko; Nishiyama, Haruka; Tanahashi, Hiromasa; Kawakita, Kento; Tsurugi, Hayato; Mashima, Kazushi
Journal of the American Chemical Society, 2014 , vol. 136, # 13 p. 5161 - 5170
反应条件
1.1: LDA / hexane; tetrahydrofuran / cooling
1.2: hexane; tetrahydrofuran
2.1: LiCl / dimethylformamide / 5 h / 30 °C
3.1: aq. HCl / dimethylformamide / 0.08 h
View Scheme
参考文献
Miura, Katsukiyo; Nakagawa, Takahiro; Hosomi, Akira
Synlett, 2005 , # 12 art. no. U14605ST, p. 1917 - 1921
反应条件
1: LiCl / dimethylformamide / 5 h / 30 °C
2: aq. HCl / dimethylformamide / 0.08 h
View Scheme
参考文献
Miura, Katsukiyo; Nakagawa, Takahiro; Hosomi, Akira
Synlett, 2005 , # 12 art. no. U14605ST, p. 1917 - 1921
反应条件
boron trifluoride diethyl etherate; diisobutylaluminium hydride
1) CH2Cl2/toluene, -78 deg C, 1 h, 2) CH2Cl2, -78 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Kiyooka, Syun-ichi; Shirouchi, Masashi
Journal of Organic Chemistry, 1992 , vol. 57, # 1 p. 1 - 2
反应条件
1: POCl3, Py
2: LiAlH4
3: (i) Py, CF3CO2H, DCC, DMSO, (ii) oxalic acid
View Scheme
参考文献
Bullivant,M.J.; Pattenden,G.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1976 , p. 256 - 258
反应条件
1: POCl3, Py
2: LiAlH4
View Scheme
参考文献
Bullivant,M.J.; Pattenden,G.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1976 , p. 256 - 258