3-(3,4-二甲氧基苯基)-3-氧丙酸甲酯合成路线 （共 11 条）
反应条件
hydrazine in ethanol
参考文献
Arnost, Michael; Pierce, Al; Haar, Ernst ter; Lauffer, David; Madden, Jaren; Tanner, Kirk; Green, Jeremy
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 5 p. 1661 - 1664
反应条件
sodium hydride in tetrahydrofuran
5 h; Heating;
参考文献
Pericas, Lex; Shafir, Alexandr; Vallribera, Adelina
Organic Letters, 2013 , vol. 15, # 7 p. 1448 - 1451
反应条件
Cu(II)-Mont K 10 clay in benzene
T=80°C; Condensation; 5 h;
参考文献
Phukan, Prodeep; Mohan, Jakkam Madan; Sudalai, Arumugam
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 24 p. 3685 - 3689
反应条件
1: thionyl chloride, pyridine / benzene / 0.5 h / Heating
2: 2.) NH4Cl, 28percent aq. NH4OH / 1.) ether, reflux, 3 h, 2.) 100 deg C
View Scheme
参考文献
Toda, Jun; Niimura, Yoshihiro; Takeda, Kaoru; Sano, Takehiro; Tsuda, Yoshisuke
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 6 p. 906 - 912
参考文献
Yamauchi, Satoshi; Ishibashi, Fumito; Taniguchi, Eiji
Bioscience, Biotechnology, and Biochemistry, 1992 , vol. 56, # 11 p. 1760 - 1768
反应条件
ammonium hydroxide; ammonium chloride
1.) ether, reflux, 3 h, 2.) 100 deg C; Yield given. Multistep reaction;
参考文献
Toda, Jun; Niimura, Yoshihiro; Takeda, Kaoru; Sano, Takehiro; Tsuda, Yoshisuke
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 6 p. 906 - 912
反应条件
salcomine; oxygen
1.) methanol, 25 deg C, 10 atm, 72 h, 2.) methanol, ether; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Bassoli, Angela; Gregorio, Giuseppina Di; Rindone, Bruno; Tollari, Stefano; Chioccara, Francesco; Salmona, Mario
Gazzetta Chimica Italiana, 1988 , vol. 118, # 11 p. 763 - 768
参考文献
Martinet, Sophie; Meou, Alain; Brun, Pierre
European Journal of Organic Chemistry, 2009 , # 14 p. 2306 - 2311
反应条件
Yield given. Multistep reaction;
参考文献
Bassoli, Angela; Gregorio, Giuseppina Di; Rindone, Bruno; Tollari, Stefano; Chioccara, Francesco; Salmona, Mario
Gazzetta Chimica Italiana, 1988 , vol. 118, # 11 p. 763 - 768
反应条件
1: aq. KOH / 24 h / 20 °C
2: aq. phosphate buffer / 60 h / 20 °C / pH 7.0
View Scheme
参考文献
Sharma, Vedula M.; Adi Seshu; Vamsee Krishna; Prasanna; Chandra Sekhar; Venkateswarlu; Rajagopal, Sriram; Ajaykumar; Deevi, Dhanvanthri S.; Rao Mamidi; Rajagopalan
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 10 p. 1679 - 1682
