(5AS,10BR)-(-)-5A,10B-二氢-2-(五氟苯基)-4H,6H-茚[2,1-B][1,2,4]三唑[4,3-D][1,4]醇四氟硼酸恶嗪合成路线 （共 3 条）
反应条件
1: morpholin-2-one With trimethyl-oxonium tetrafluoroborate in dichloromethane
T=20°C; Inert atmosphere;
2: pentafluorophenyl hydrazine in dichloromethane
T=100°C; P=2 Torr; 5 h;
3: orthoformic acid triethyl ester; chlorobenzene in dichloromethane
T=130°C; 72 h; Inert atmosphere;
参考文献
COLORADO STATE UNIVERSITY RESEARCH FOUNDATION
Patent: US2011/224431 A1, 2011 ;
Location in patent: Page/Page column 7 ;
反应条件
in chlorobenzene
T=110°C; 24 h;
参考文献
Kerr, Mark S.; Read De Alaniz, Javier; Rovis, Tomislav
Journal of Organic Chemistry, 2005 , vol. 70, # 14 p. 5725 - 5728
反应条件
1: (4aR,9aS)-4,4a,9,9a-tetrahydro-1-oxa-4-azafluoren-3-one; trimethyl-oxonium tetrafluoroborate in dichloromethane
T=20°C; Inert atmosphere;
2: pentafluorophenyl hydrazine in dichloromethane
T=20°C; 4 h; Inert atmosphere;
3: orthoformic acid triethyl ester in chlorobenzene
T=130°C; 72 h;
参考文献
Vora, Harit U.; Lathrop, Stephen P.; Reynolds, Nathan T.; Kerr, Mark S.; De Alaniz, Javier Read; Rovis, Tomislav; Chennamadhavuni, Spandan; Davies, Huw M. L.
Organic Syntheses, 2010 , vol. 87, p. 350 - 361
