N-[3-[4-[4-[(环己基甲基磺酰基)氨基]丁基]哌嗪-1-基]苯基]乙酰胺合成路线 （共 5 条）
反应条件
triethylamine in dichloromethane
T=20°C; 0.5 h;
参考文献
Becker, Oren M.; Dhanoa, Dale S.; Marantz, Yael; Chen, Dongli; Shacham, Sharon; Cheruku, Srinivasa; Heifetz, Alexander; Mohanty, Pradyumna; Fichman, Merav; Sharadendu, Anurag; Nudelman, Raphael; Kauffman, Michael; Noiman, Silvia
Journal of Medicinal Chemistry, 2006 , vol. 49, # 11 p. 3116 - 3135
反应条件
1: CH2Cl2 / 2 h / 0 °C
2: 88 percent / Et3N / CH2Cl2 / 0.5 h / 20 °C
3: 76 percent / SnCl2; aq. HCl / methanol / -10 - 20 °C
4: 89 percent / Et3N / CH2Cl2 / 0.5 h / 20 °C
View Scheme
参考文献
Becker, Oren M.; Dhanoa, Dale S.; Marantz, Yael; Chen, Dongli; Shacham, Sharon; Cheruku, Srinivasa; Heifetz, Alexander; Mohanty, Pradyumna; Fichman, Merav; Sharadendu, Anurag; Nudelman, Raphael; Kauffman, Michael; Noiman, Silvia
Journal of Medicinal Chemistry, 2006 , vol. 49, # 11 p. 3116 - 3135
反应条件
1: 76 percent / SnCl2; aq. HCl / methanol / -10 - 20 °C
2: 89 percent / Et3N / CH2Cl2 / 0.5 h / 20 °C
View Scheme
参考文献
Becker, Oren M.; Dhanoa, Dale S.; Marantz, Yael; Chen, Dongli; Shacham, Sharon; Cheruku, Srinivasa; Heifetz, Alexander; Mohanty, Pradyumna; Fichman, Merav; Sharadendu, Anurag; Nudelman, Raphael; Kauffman, Michael; Noiman, Silvia
Journal of Medicinal Chemistry, 2006 , vol. 49, # 11 p. 3116 - 3135
反应条件
1: 63 percent / Et3N / tetrahydrofuran / 48 h / 20 °C
2: CH2Cl2 / 2 h / 0 °C
3: 88 percent / Et3N / CH2Cl2 / 0.5 h / 20 °C
4: 76 percent / SnCl2; aq. HCl / methanol / -10 - 20 °C
5: 89 percent / Et3N / CH2Cl2 / 0.5 h / 20 °C
View Scheme
参考文献
Becker, Oren M.; Dhanoa, Dale S.; Marantz, Yael; Chen, Dongli; Shacham, Sharon; Cheruku, Srinivasa; Heifetz, Alexander; Mohanty, Pradyumna; Fichman, Merav; Sharadendu, Anurag; Nudelman, Raphael; Kauffman, Michael; Noiman, Silvia
Journal of Medicinal Chemistry, 2006 , vol. 49, # 11 p. 3116 - 3135
反应条件
1: 45 percent / K2CO3 / chlorobenzene / 48 h / Heating
2: 63 percent / Et3N / tetrahydrofuran / 48 h / 20 °C
3: CH2Cl2 / 2 h / 0 °C
4: 88 percent / Et3N / CH2Cl2 / 0.5 h / 20 °C
5: 76 percent / SnCl2; aq. HCl / methanol / -10 - 20 °C
6: 89 percent / Et3N / CH2Cl2 / 0.5 h / 20 °C
View Scheme
参考文献
Becker, Oren M.; Dhanoa, Dale S.; Marantz, Yael; Chen, Dongli; Shacham, Sharon; Cheruku, Srinivasa; Heifetz, Alexander; Mohanty, Pradyumna; Fichman, Merav; Sharadendu, Anurag; Nudelman, Raphael; Kauffman, Michael; Noiman, Silvia
Journal of Medicinal Chemistry, 2006 , vol. 49, # 11 p. 3116 - 3135
