1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C / Inert atmosphere 1.2: 1 h / 60 °C / Inert atmosphere 2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 - 20 °C / Inert atmosphere 3.1: trifluoroacetic acid / toluene / 48 h / 20 °C 4.1: triethylamine / dichloromethane / 1 h / 20 °C 5.1: potassium phosphate; tetrakis(triphenylphosphine) palladium(0); potassium bromide / 1,4-dioxane / 2 h / Inert atmosphere; Reflux View Scheme

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C / Inert atmosphere 1.2: 1 h / 60 °C / Inert atmosphere 2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 - 20 °C / Inert atmosphere 3.1: trifluoroacetic acid / toluene / 48 h / 20 °C 4.1: triethylamine / dichloromethane / 1 h / 20 °C 5.1: potassium phosphate; tetrakis(triphenylphosphine) palladium(0); potassium bromide / 1,4-dioxane / 1 h / Inert atmosphere; Reflux View Scheme