(2E)-3-[1-(2-脱氧-BETA-D-赤式戊呋喃糖基)-1,2,3,4-四氢-2,4-二氧代-5-嘧啶基]-2-丙烯酸合成路线 （共 9 条）
反应条件
sodium hydroxide in methanol 2 h;
参考文献
Rong; Soloway
Nucleosides and Nucleotides, 1994 , vol. 13, # 9 p. 2021 - 2034
反应条件
hydrogenchloride; sodium hydroxide; triethylamine; triphenylphosphine; palladium diacetate in 1,4-dioxane; water
参考文献
RIKEN; KABUSHIKI KAISHA DNAFORM
Patent: US2008/227104 A1, 2008 ;
反应条件
triethylamine; triphenylphosphine; palladium diacetate in 1,4-dioxane T=125°C; 1 h;
参考文献
EP2130835 A1, ;
Page/Page column 40 ;
反应条件
Amberlite IRA-67; palladium on activated charcoal in N,N-dimethyl-formamide T=50°C; Heck reaction; 6 h;
参考文献
Garg, Neil K.; Woodroofe, Carolyn C.; Lacenere, Christopher J.; Quake, Stephen R.; Stoltz, Brian M.
Chemical Communications, 2005 , # 36 p. 4551 - 4553
反应条件
1: 100 percent / Pd(OAc)2, Ph3P, Et3N / dioxane / 14 h / Heating 2: 89.7 percent / aq. NaOH / methanol / 2 h View Scheme
参考文献
Nucleosides and Nucleotides, , vol. 13, # 9 p. 2021 - 2034
反应条件
N-bromosuccinmide in tetrahydrofuran; water T=25°C; 0.5 h;
参考文献
Johar, Monika; Manning, Tracey; Kunimoto, Dennis Y.; Kumar, Rakesh
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 24 p. 6663 - 6671
反应条件
N-bromosuccinmide; potassium carbonate in N,N-dimethyl-formamide T=20°C; 0.5 h;
参考文献
Tetrahedron, , vol. 43, # 20 p. 4601 - 4608
反应条件
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in N,N-dimethyl-formamide
T=25°C; 3 h; Product distribution / selectivity;
参考文献
RIKEN; Okamoto, Akimitsu; Ikeda, Shuji
Patent: US2013/289263 A1, 2013 ;
Location in patent: Paragraph 0206-0207 ;
反应条件
water; triethylamine in N,N-dimethyl-formamide
T=105°C; 24 h;
参考文献
Jones, A. Stanley; McClean, Michael J.; Slater, Martin J.; Walker, Richard T.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 457 - 464
