3-氰基-4-甲氧基吡啶合成路线 （共 10 条）
反应条件
in methanol T=20°C; 1 h;
参考文献
Takeda Chemical Industries, Ltd.; Kusaka, Masami
Patent: EP1348706 A1, 2003 ;
Location in patent: Page/Page column 39 ;
反应条件
hydrogen; triethylamine; palladium dichloride in N,N-dimethyl-formamide P=2574.3 Torr; 2 h; Ambient temperature;
参考文献
Mittelbach; Kastner; Junek
Archiv der Pharmazie, 1985 , vol. 318, # 6 p. 481 - 486
反应条件
1: With hydroxylamine hydrochloride in methanol T=25°C; 4 h; 2: With pyridine; methanesulfonyl chloride T=25°C; 2 h;
参考文献
French, Jarrod B.; Cen, Yana; Vrablik, Tracy L.; Xu, Ping; Allen, Eleanor; Hanna-Rose, Wendy; Sauve, Anthony A.
Biochemistry, 2010 , vol. 49, # 49 p. 10421 - 10439
反应条件
hydrogen; triethylamine; palladium dichloride in N,N-dimethyl-formamide P=2574.3 Torr; 2 h; Ambient temperature;
参考文献
Archiv der Pharmazie, , vol. 318, # 6 p. 481 - 486
反应条件
1: 83 percent / HCl / methanol 2: triethylamine, H2 / PdCl2 / dimethylformamide / 2 h / 2574.3 Torr / Ambient temperature View Scheme
参考文献
Archiv der Pharmazie, , vol. 318, # 6 p. 481 - 486
反应条件
1.1: 2-Bromo-1,3,5-trimethyl-benzene; tert.-butyl lithium / tetrahydrofuran; pentane / 3 h / -78 - 20 °C 1.2: 1 h / -78 °C 2.1: hydroxylamine hydrochloride / methanol / 4 h / 25 °C 2.2: 2 h / 25 °C View Scheme
参考文献
Biochemistry, , vol. 49, # 49 p. 10421 - 10439
反应条件
hydrogenchloride; water Diazotization;
参考文献
med. Ch. I. G., , vol. 2, p. 384,388
反应条件
hydrogenchloride 6.5 h; Heating;
参考文献
Mittelbach; Kastner; Junek
Archiv der Pharmazie, 1985 , vol. 318, # 6 p. 481 - 486
反应条件
dimethyl sulfate; benzene Behandeln des Reaktionsprodukts mit K3<Fe(CN)6> in H2O;
参考文献
Reitmann
Med. Ch. I. G., 1934 , vol. 2, p. 384,388
反应条件
dihydrogen peroxide; potassium carbonate in dimethyl sulfoxide
1 h;
参考文献
French, Jarrod B.; Cen, Yana; Vrablik, Tracy L.; Xu, Ping; Allen, Eleanor; Hanna-Rose, Wendy; Sauve, Anthony A.
Biochemistry, 2010 , vol. 49, # 49 p. 10421 - 10439
