2-溴-6-(甲基硫代)吡啶合成路线 （共 8 条）
反应条件
1: 61 percent / 30percent hydrogen peroxide / acetic acid / 24 h 2: 50 percent / EtMgBr / diethyl ether; tetrahydrofuran / 1 h / Ambient temperature View Scheme
参考文献
Oae, Shigeru; Kawai, Tsutomu; Furukawa, Naomichi
Phosphorus and Sulfur and the Related Elements, 1987 , vol. 34, p. 123 - 132
反应条件
tetrabutylammomium bromide in water; benzene
6 h; Heating;
参考文献
Furukawa, Naomichi; Ogawa, Satoshi; Kawai, Tsutomu; Oae, Shigeru
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 8 p. 1839 - 1845
反应条件
1: 2,6-Dibromopyridine With isopropylmagnesium chloride in tetrahydrofuran
T=20°C; Substitution; 2 h;
2: dimethyl-disulfide in tetrahydrofuran
T=20°C; Substitution; 18 h;
参考文献
Trecourt, Francois; Breton, Gilles; Bonnet, Veronique; Mongin, Florence; Marsais, Francis; Queguiner, Guy
Tetrahedron, 2000 , vol. 56, # 10 p. 1349 - 1360
反应条件
2-mercaptoethanesulphonic acid sodium salt in N,N-dimethyl-formamide
Ambient temperature;
参考文献
Testaferri, Lorenzo; Tiecco, Marcello; Tingoli, Marco; Bartoli, Donatella; Massoli, Alberto
Tetrahedron, 1985 , vol. 41, # 7 p. 1373 - 1384
反应条件
sodium hydroxide; tetrabutylammomium bromide in water; benzene
6 h; Heating;
参考文献
Furukawa, Naomichi; Ogawa, Satoshi; Kawai, Tsutomu; Oae, Shigeru
Tetrahedron Letters, 1983 , vol. 24, # 31 p. 3243 - 3246
参考文献
Oae, Shigeru; Kawai, Tsutomu; Furukawa, Naomichi
Phosphorus and Sulfur and the Related Elements, 1987 , vol. 34, p. 123 - 132
反应条件
methanol; n-butyllithium
1.) THF, -89 deg C, 4.5 h, 2.) THF, from -90 deg C to RT, 6 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Newkome, George R.; Roper, Jerry M.
Journal of Organometallic Chemistry, 1980 , vol. 186, # 2 p. 147 - 153
反应条件
3-chloro-benzenecarboperoxoic acid in dichloromethane
T=20°C; 2 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2006/102194 A1, 2006 ;
Location in patent: Page/Page column 70 ;
WO 2006/102194 A1
