(S)-(-)-1,2,3,4-四氢异喹啉-3-羧酸合成路线 （共 45 条）
反应条件
hydrogenchloride T=85°C; Pictet-Spengler condensation; 9 h;
参考文献
Liu, Jiawang; Cui, Guohui; Zhao, Ming; Cui, Chunying; Ju, Jingfang; Peng, Shiqi
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 24 p. 7773 - 7788
反应条件
sodium hydroxide in water 15 h; Ambient temperature;
参考文献
Kammermeier; Lerch; Sommer
Synthesis, 1992 , # 11 p. 1157 - 1160
反应条件
water in isopropyl alcohol T=20°C;
参考文献
Spengler; Schedel; Sieler; Quaedflieg; Broxterman; Duchateau; Burger
Synthesis, 2001 , # 10 p. 1513 - 1518
反应条件
hydrogenchloride; Dowex 50-WX8; acetic acid in water; toluene T=103°C; 126 h;
参考文献
Seebach, Dieter; Dziadulewicz, Edward; Behrendt, Linda; Cantoreggi, Sergio; Fitzi, Robert
Liebigs Annalen der Chemie, 1989 , p. 1215 - 1232
反应条件
sodium hydroxide in methanol 6 h; Ambient temperature;
参考文献
Kammermeier; Lerch; Sommer
Synthesis, 1992 , # 11 p. 1157 - 1160
反应条件
in hydrogenchloride; ethanol; water
参考文献
US6403561 B1, ;
US 6403561 B1
参考文献
Bulletin of the Chemical Society of Japan, , vol. 64, # 12 p. 3729 - 3731
反应条件
1: With sodium hydroxide in acetonitrile T=20°C; 0.666667 h; 2: in hydrogenchloride; methanol T=50°C; 0.333333 h; 3: in ammonium hydroxide
参考文献
Mendeleev Communications, , vol. 13, # 3 p. 132 - 134
反应条件
1: 91 percent / dimethylsulfoxide 2: 65 percent / SOCl2 3: BF3*OEt2 / 20 °C 4: 72 percent / H2O / propan-2-ol / 20 °C View Scheme
参考文献
Synthesis, , # 10 p. 1513 - 1518
反应条件
1: 65 percent / SOCl2 2: BF3*OEt2 / 20 °C 3: 72 percent / H2O / propan-2-ol / 20 °C View Scheme
参考文献
Synthesis, , # 10 p. 1513 - 1518
