(S)-(-)-1,2,3,4-四氢异喹啉-3-羧酸合成路线 （共 45 条）
反应条件
1: 98 percent / NaOH / dioxane; H2O / 12 h / 20 °C 2: 98 percent / NH4Cl; HOBt; EDCI / dimethylformamide / 20 °C 3: 100 percent / HCl / tetrahydrofuran; diethyl ether / 12 h / 20 °C View Scheme
参考文献
Charton, Julie; Gassiot, Amaury Cazenave; Melnyk, Patricia; Girault-Mizzi, Sophie; Sergheraert, Christian
Tetrahedron Letters, 2004 , vol. 45, # 38 p. 7081 - 7085
反应条件
dimethylsulfide borane complex; boron trifluoride diethyl etherate in tetrahydrofuran Reduction; 6 h; Heating;
参考文献
Aggarwal, Varinder K.; Humphries, Paul S.; Fenwick, Ashley
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 20 p. 2883 - 2889
反应条件
1: COCl2
3: 85 percent / H2 / Rh/Alox / ethyl acetate / 150 °C / 112509 Torr
4: dimethylformamide / 120 °C
5: 1.) MeNH2, 2.) HCl
View Scheme
参考文献
Goehring, Wolfgang; Gokhale, Surendra; Hilpert, Hans; Roessler, Felix; Schlageter, Markus; Vogt, Peter
Chimia, 1996 , vol. 50, # 11 p. 532 - 537
参考文献
Jansa, Petr; Wsol, Vladimir; Bertolasi, Valerio; Machacek, Vladimir
Heterocycles, 2006 , vol. 68, # 12 p. 2527 - 2547
反应条件
dimethylsulfide borane complex; boron trifluoride diethyl etherate in tetrahydrofuran
Reduction; 6 h; Heating;
参考文献
Aggarwal, Varinder K.; Humphries, Paul S.; Fenwick, Ashley
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 20 p. 2883 - 2889
