2-(7H-吡咯[2,3-D]嘧啶-4-基)-N-异吲哚-1,3-二酮合成路线 （共 4 条）
反应条件
in N,N-dimethyl acetamide; water T=10 - 80°C; 12 h;
参考文献
WO2004/72090 A1, ;
Page 11 ;
反应条件
N,N-dimethyl acetamide; N-ethyl-N,N-diisopropylamine
参考文献
Bio, Matthew M.; Xu, Feng; Waters, Marjorie; Williams, J. Michael; Savary, Kimberly A.; Cowden, Cameron J.; Yang, Chunhua; Buck, Elizabeth; Song, Zhiguo J.; Tschaen, David M.; Volante; Reamer, Robert A.; Grabowski, Edward J. J.
Journal of Organic Chemistry, 2004 , vol. 69, # 19 p. 6257 - 6266
反应条件
1: 84 percent / sulfuric acid / 5.5 h / 20 - 75 °C 2: 85.6 percent / N,N-dimethylacetamide; N,N-diisopropylethylamine View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 19 p. 6257 - 6266
反应条件
1: 99.1 percent / aq. KOH; hydrogen peroxide / 5 - 15 °C 2: 84 percent / sulfuric acid / 5.5 h / 20 - 75 °C 3: 85.6 percent / N,N-dimethylacetamide; N,N-diisopropylethylamine View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 19 p. 6257 - 6266
