1: With methanol; lithium hydroxide; water in 1,4-dioxane T=20 - 50°C; 48 h; 2: With hydrogenchloride in 1,4-dioxane; water pH=6;

diazomethyl-trimethyl-silane in hexanes; benzene T=20°C; 4 h;

1: methyl N-tert-butoxycarbonyl-piperidine-4-carboxylate With lithium diisopropyl amide in tetrahydrofuran; N,N,N',N',N'',N''-hexamethylphosphoric triamide; hexanes T=-78°C; 1 h; 2: benzyl bromide in tetrahydrofuran; N,N,N',N',N'',N''-hexamethylphosphoric triamide; hexanes T=20°C; 20 h;

1: methyl N-tert-butoxycarbonyl-piperidine-4-carboxylate With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-78°C; 1.5 h; 2: benzyl bromide in tetrahydrofuran; hexane T=-78°C; 2.5 h;