反应条件
1: 2-bromo-4,5-difluoroanisole With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 2: 4-amino-2-ethylsulfanylpyrimidine-5-carboxylic acid metoxymethylamide in tetrahydrofuran; hexane T=-78 - -35°C; 2 h;
参考文献
Chu, Xin-Jie; DePinto, Wanda; Bartkovitz, David; So, Sung-Sau; Vu, Binh T.; Packman, Kathryn; Lukacs, Christine; Ding, Qingjie; Jiang, Nan; Wang, Ka; Goelzer, Petra; Yin, Xuefeng; Smith, Melissa A.; Higgins, Brian X.; Chen, Yingsi; Xiang, Qing; Moliterni, John; Kaplan, Gerald; Graves, Bradford; Lovey, Allen; Fotouhi, Nader
Journal of Medicinal Chemistry, 2006 , vol. 49, # 22 p. 6549 - 6560
