1: (4-amino-2-ethylsulfanylpyrimidin-5-yl)(2,3-difluoro-6-methoxyphenyl)methanone With 3-chloro-benzenecarboperoxoic acid in chloroform T=-15°C; 1 h; 2: 1-(methylsulfonyl)piperidin-4-amine in isopropyl alcohol T=100 - 110°C; 1 h; microwave irradiation;

1.1: n-BuLi / tetrahydrofuran; hexane / -78 °C 1.2: tetrahydrofuran; hexane / 2 h / -78 - -35 °C 2.1: m-CPBA / CHCl3 / 1 h / -15 °C 2.2: propan-2-ol / 1 h / 100 - 110 °C / microwave irradiation View Scheme

1.1: CF3CO2H / CH2Cl2 / 2 h / 20 °C 2.1: m-CPBA / CHCl3 / 1 h / -15 °C 2.2: propan-2-ol / 1 h / 100 - 110 °C / microwave irradiation View Scheme

1.1: HOBt; HBTU; DIPEA / dimethylformamide / 0.25 h / 0 °C 1.2: 98 percent / dimethylformamide / 2 h / 0 - 20 °C 2.1: n-BuLi / tetrahydrofuran; hexane / -78 °C 2.2: tetrahydrofuran; hexane / 2 h / -78 - -35 °C 3.1: m-CPBA / CHCl3 / 1 h / -15 °C 3.2: propan-2-ol / 1 h / 100 - 110 °C / microwave irradiation View Scheme

1.1: DIPEA / tetrahydrofuran / 1 h / 5 - 20 °C 2.1: CF3CO2H / CH2Cl2 / 2 h / 20 °C 3.1: m-CPBA / CHCl3 / 1 h / -15 °C 3.2: propan-2-ol / 1 h / 100 - 110 °C / microwave irradiation View Scheme