1-溴-2,5-二氟-3-硝基苯合成路线 （共 3 条）
反应条件
1: With mercury(II) oxide in tetrachloromethane
T=20°C; Heating / refluxIrradiation;
2: With bromine in tetrachloromethane
0.166667 h; Heating / reflux;
参考文献
WARNER-LAMBERT COMPANY LLC
Patent: WO2004/69832 A2, 2004 ;
Location in patent: Page 134 ;
反应条件
bromine; mercury(II) oxide in tetrachloromethane
light;
参考文献
Vara Prasad; Boyer, Frederick E.; Chupak, Lou; Dermyer, Michael; Ding, Qizhu; Gavardinas; Hagen, Susan E.; Huband, Michael D.; Jiao, Wenhua; Kaneko, Takushi; Maiti, Samarendra N.; Melnick, Michael; Romero, Karina; Patterson; Wu, Xiujuan
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 20 p. 5392 - 5397
反应条件
1: 72 percent / nitric acid; sulfuric acid
2: 38 percent / Br2; HgO / CCl4 / light
View Scheme
参考文献
Vara Prasad; Boyer, Frederick E.; Chupak, Lou; Dermyer, Michael; Ding, Qizhu; Gavardinas; Hagen, Susan E.; Huband, Michael D.; Jiao, Wenhua; Kaneko, Takushi; Maiti, Samarendra N.; Melnick, Michael; Romero, Karina; Patterson; Wu, Xiujuan
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 20 p. 5392 - 5397
