1: 90 percent / pyridine / Ambient temperature 2: 70 percent / NaH / dimethylformamide / Ambient temperature 3: 92 percent / H2 / 10 percent Pd/C / ethyl acetate / Ambient temperature 4: 75 percent / DBU / 1,2-dichloro-ethane / Ambient temperature 5: trimethylsilyl trifluoromethanesulfonate / 1,2-dichloro-ethane / 0.08 h / Ambient temperature 6: 95 percent / Bu4NF / tetrahydrofuran / Ambient temperature 7: 88 percent / pyridine / Ambient temperature View Scheme

1: 85 percent / HCl / 20 °C 2: 90 percent / pyridine / Ambient temperature 3: 70 percent / NaH / dimethylformamide / Ambient temperature 4: 92 percent / H2 / 10 percent Pd/C / ethyl acetate / Ambient temperature 5: 75 percent / DBU / 1,2-dichloro-ethane / Ambient temperature 6: trimethylsilyl trifluoromethanesulfonate / 1,2-dichloro-ethane / 0.08 h / Ambient temperature 7: 95 percent / Bu4NF / tetrahydrofuran / Ambient temperature 8: 88 percent / pyridine / Ambient temperature View Scheme

1: 70 percent / NaH / dimethylformamide / Ambient temperature 2: 92 percent / H2 / 10 percent Pd/C / ethyl acetate / Ambient temperature 3: 75 percent / DBU / 1,2-dichloro-ethane / Ambient temperature 4: trimethylsilyl trifluoromethanesulfonate / 1,2-dichloro-ethane / 0.08 h / Ambient temperature 5: 95 percent / Bu4NF / tetrahydrofuran / Ambient temperature 6: 88 percent / pyridine / Ambient temperature View Scheme

1: 92 percent / H2 / 10 percent Pd/C / ethyl acetate / Ambient temperature 2: 75 percent / DBU / 1,2-dichloro-ethane / Ambient temperature 3: trimethylsilyl trifluoromethanesulfonate / 1,2-dichloro-ethane / 0.08 h / Ambient temperature 4: 95 percent / Bu4NF / tetrahydrofuran / Ambient temperature 5: 88 percent / pyridine / Ambient temperature View Scheme

pyridine Ambient temperature;

1: 2 h / Heating 2: trimethylsilyl trifluoromethanesulfonate / 1,2-dichloro-ethane / 0.08 h / Ambient temperature 3: 95 percent / Bu4NF / tetrahydrofuran / Ambient temperature 4: 88 percent / pyridine / Ambient temperature View Scheme

1: trimethylsilyl trifluoromethanesulfonate / 1,2-dichloro-ethane / 0.08 h / Ambient temperature 2: 95 percent / Bu4NF / tetrahydrofuran / Ambient temperature 3: 88 percent / pyridine / Ambient temperature View Scheme

1: 75 percent / DBU / 1,2-dichloro-ethane / Ambient temperature 2: trimethylsilyl trifluoromethanesulfonate / 1,2-dichloro-ethane / 0.08 h / Ambient temperature 3: 95 percent / Bu4NF / tetrahydrofuran / Ambient temperature 4: 88 percent / pyridine / Ambient temperature View Scheme

1: trimethylsilyl trifluoromethanesulfonate / 1,2-dichloro-ethane / 0.08 h / Ambient temperature 2: 95 percent / Bu4NF / tetrahydrofuran / Ambient temperature 3: 88 percent / pyridine / Ambient temperature View Scheme

1: 95 percent / Bu4NF / tetrahydrofuran / Ambient temperature 2: 88 percent / pyridine / Ambient temperature View Scheme