2-(叔丁基二甲基硅杂氧基)环己酮合成路线 （共 13 条）
反应条件
sodium chloride in water; dimethyl sulfoxide T=130°C; 0.5 h;
参考文献
Drew, Michael G. B.; Harwood, Laurence M.; Macias-Sanchez, Antonio J.; Scott, Richard; Thomas; Uguen, Daniel
Angewandte Chemie - International Edition, 2001 , vol. 40, # 12 p. 2311 - 2313
反应条件
1H-imidazole; 4-(N,N-dimethlyamino)pyridine in dichloromethane T=20°C; 2 h;
参考文献
Drew, Michael G. B.; Harwood, Laurence M.; Macias-Sanchez, Antonio J.; Scott, Richard; Thomas; Uguen, Daniel
Angewandte Chemie - International Edition, 2001 , vol. 40, # 12 p. 2311 - 2313
反应条件
1H-imidazole in N,N-dimethyl-formamide T=0°C; 15 h;
参考文献
Araki, Yoshiharu; Miyawaki, Arisa; Miyashita, Tomoyuki; Mizutani, Masaharu; Hirai, Nobuhiro; Todoroki, Yasushi
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 12 p. 3302 - 3305
反应条件
1.1: dimethyldioxirane / acetone; CH2Cl2 / 0.17 h 1.2: 70 percent / 10-camphorsulfonic acid / acetone / 0.5 h 2.1: 91 percent / imidazole; 4-dimethylaminopyridine / CH2Cl2 / 2 h / 20 °C 3.1: 100 percent / NaCl / dimethylsulfoxide; H2O / 0.5 h / 130 °C View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 40, # 12 p. 2311 - 2313
反应条件
1.1: 99 percent / 10-camphorsulfonic acid / methanol / 16 h / Heating 2.1: 92 percent / lithium diisopropylamide / tetrahydrofuran / 1 h / -40 °C 3.1: dimethyldioxirane / acetone; CH2Cl2 / 0.17 h 3.2: 70 percent / 10-camphorsulfonic acid / acetone / 0.5 h 4.1: 91 percent / imidazole; 4-dimethylaminopyridine / CH2Cl2 / 2 h / 20 °C 5.1: 100 percent / NaCl / dimethylsulfoxide; H2O / 0.5 h / 130 °C View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 40, # 12 p. 2311 - 2313
反应条件
1.1: 92 percent / lithium diisopropylamide / tetrahydrofuran / 1 h / -40 °C 2.1: dimethyldioxirane / acetone; CH2Cl2 / 0.17 h 2.2: 70 percent / 10-camphorsulfonic acid / acetone / 0.5 h 3.1: 91 percent / imidazole; 4-dimethylaminopyridine / CH2Cl2 / 2 h / 20 °C 4.1: 100 percent / NaCl / dimethylsulfoxide; H2O / 0.5 h / 130 °C View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 40, # 12 p. 2311 - 2313
反应条件
1: 91 percent / imidazole; 4-dimethylaminopyridine / CH2Cl2 / 2 h / 20 °C 2: 100 percent / NaCl / dimethylsulfoxide; H2O / 0.5 h / 130 °C View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 40, # 12 p. 2311 - 2313
反应条件
nickel in ethanol 0.5 h; Ambient temperature;
参考文献
Kita, Yasuyuki; Tamura, Osamu; Yasuda, Hitoshi; Itoh, Fumio; Tamura, Yasumitsu
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 10 p. 4235 - 4241
反应条件
1: 75 percent / zinc iodide / acetonitrile / r.t. 1 h., 70 deg C. 14 h. 2: 61 percent / Raney nickel / ethanol / 0.5 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 33, # 10 p. 4235 - 4241
反应条件
1: 75 percent / zinc iodide / acetonitrile / r.t. 1 h., 70 deg C. 14 h. 2: 61 percent / Raney nickel / ethanol / 0.5 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 33, # 10 p. 4235 - 4241
